University of Groningen
Genetic and lifestyle risks of cardiovascular disease
Said, M. Abdullah
DOI:
10.33612/diss.157192207
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Publication date: 2021
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Citation for published version (APA):
Said, M. A. (2021). Genetic and lifestyle risks of cardiovascular disease. University of Groningen. https://doi.org/10.33612/diss.157192207
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COLOPHON
Cover design: James Jardine | www.jamesjardine.nl Layout: James Jardine | www.jamesjardine.nl Print: Ridderprint | www.ridderprint.nl
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Financial support by the following sponsor for the publication of this thesis is gratefully acknowledged: Rijksuniversiteit Groningen, Groningen University Institute for Drug Exploration (GUIDE).
Copyright © 2021 by Mir Abdullah Said. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications
Genetic and lifestyle risks of
cardiovascular disease
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 17 februari 2021 om 16.15 uur
door
Mir Abdullah Said
geboren op 1 juli 1994 te Kabul, Afghanistan
Promotor
Prof. dr. P. van der Harst Copromotor
Dr. N. Verweij
Beoordelingscommissie Prof. dr. H. Snieder
Prof. dr. R.A. de Boer Prof. dr. L. Hofstra
Paranimfen Drs. Alwin Tubben
TABLE OF
CONTENTS
Chapter 1 Introduction 9
PART I. GENETICS OF CARDIOVASCULAR RISK FACTORS
Chapter 2 Telomere Length and Risk of Cardiovascular Disease and Cancer
23 Chapter 3 Genome wide association study and identification
of a protective missense variant on lipoprotein(a) concentration
31 Chapter 4 Genetically determined high levels of iron parameters are
protective for coronary artery disease
65
PART II. INTERPLAY OF GENETICS AND LIFESTYLE
WITH CARDIOVASCULAR DISEASE
Chapter 5 Contributions of interactions between lifestyle and genetics on coronary artery disease risk
75 Chapter 6 Associations of combined genetic and lifestyle risks with
incident cardiovascular disease and diabetes in the UK Biobank
93 Chapter 7 Genome-wide association studies and Mendelian
randomization analyses for leisure sedentary behaviours
121 Chapter 8 Associations of observational and genetically determined
caffeine intake with coronary artery disease and diabetes
159 Chapter 9 Summary and Discussion 201
