The interplay between cholesterol and inflammation in the evolution of atherosclerosis
Verschuren, L.
Citation
Verschuren, L. (2009, January 22). The interplay between cholesterol and inflammation in the evolution of atherosclerosis. Retrieved from https://hdl.handle.net/1887/13415
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13415
Note: To cite this publication please use the final published version (if applicable).
The interplay between cholesterol and inflammation in the evolution of atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 22 januari 2009 klokke 15.00 uur
door
Laurens Verschuren
geboren te Klundert in 1978
Promotiecomissie
Promotor: Prof. Dr. J.H. van Bockel Co-Promotores: Dr. R. Kleemann
Dr. T. Kooistra
Referent: Prof. Dr. R. Witkamp (Wageningen Universiteit) Overige leden: Prof. Dr. P. Quax
Prof. Dr. V.W.M. van Hinsbergh (VUMC) Dr. J.H.N. Lindeman
The research described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF-2002B102)
The studies presented in this thesis were performed at the Gaubius Laboratory, TNO- Quality of Life, Leiden, the Netherlands.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
Obstakels is dat wat je ziet als je niet gericht bent op je doel!
Henry Ford
Aan mijn ouders
Colophon
© L. Verschuren, 2009. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any mean, without the prior written permission of the author.
ISBN : 978-90-713-8281-9
Cover design : Moodfood by Claudia Roelofs, www.tomoodfood.nl
Printed by
Gildeprint Drukkerijen, Enschede
The printing of this thesis was kindly supported by:
AB diets Pfizer BV
TNO Quality of Life Tebu-Bio
AstraZeneca BV
Table of contents
Chapter 1 : 7
General Introduction
Chapter 2 : 27
Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis.
Genome Biology 2007; 8 (9): R200
Chapter 3 : 55
Evidence for anti-inflammatory activity of statins and PPARα-activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro.
Blood. 2004 Jun 1;103 (11):4188-4194
Chapter 4 : 75
Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: evidence for multiple anti-atherogenic effects besides lowering plasma cholesterol.
Atherosclerosis, Thrombosis, and Vascular Biology 2006 Oct;26 (10):2322-2330
Chapter 5 : 95
Effect of low dose atorvastatin versus diet-induced cholesterol-lowering on atherosclerotic lesion progression and inflammation in ApoE*3Leiden transgenic mice.
Atherosclerosis, Thrombosis, and Vascular Biology 2005 Jan;25 (1):161-167
Chapter 6 : 111
LXR agonist suppresses atherosclerotic lesion development and promotes lesion regression in ApoE*3Leiden mice at several levels.
Journal of Lipid Research 2009 Jan
Chapter 7 : 135
MIF deficiency reduces inflammatory state and impairs development of insulin resistance and associated atherosclerotic disease.
Submitted
Chapter 8 : 165
Up-regulation and co-expression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms.
Antioxidants and Redox Signaling 2005 Sep-Oct;7 (9-10):1195-1202
Chapter 9 : 181
Summary and general discussion
Nederlandse samenvatting 195
List of publications 203
Curriculum Vitae 205
