University of Groningen Lanthipeptide engineering: non-canonical amino acids, click chemistry and ring shuffling Deng, Jingjing

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University of Groningen

Lanthipeptide engineering: non-canonical amino acids, click chemistry and ring shuffling

Deng, Jingjing

DOI:

10.33612/diss.112973724

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Document Version

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Deng, J. (2020). Lanthipeptide engineering: non-canonical amino acids, click chemistry and ring shuffling. University of Groningen. https://doi.org/10.33612/diss.112973724

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Lis t o f Pu bli ca tio ns

List of Publications

1. Deng, J., Viel, J. H. & Kuipers, O. P. Generation of nisin derivatives with an altered spectrum by incorporating methionine analogues. Submitted.

2. Deng, J., Viel, J. H, Kubyshkin, V., Chen, J., Budisa, N. & Kuipers, O. P. Synthesis of nisin conjugates via click chemistry and their characterization. Submitted.

3. Montalban-Lopez, M.*_{Deng, J.*, van Heel, A. & Kuipers, O. P. (2018). Specificity}

and application of the lantibiotic protease NisP. Frontiers in microbiology 9:160, doi: 10.3389/fm icb.2018.00160.

4. Deng, J. & Lu, C. (2015). Two new isoflavone 7-O-α-4˝-anhydro-4˝,5˝-didehydro-glucuronides from Streptomyces sp. LZ35 ΔgdmAI. Natural product research 30 (2), 1–5, doi: 10.1080/14786419.2015.1046869.

5. Xie, C.*_{, Deng, J.*, Wang, H. & Shen, Y. (2015). Activation of a silent ansatrienin gene}

cluster by constitutive expression of LAL family regulator gene in Streptomyces sp. XZQH13. Current microbiology 70 (6), 859–864, doi: 10.1007/s00284-015-0798-6. 6. Deng, J., Lu, C., Li, S., Hao, H., Li, Z., Zhu, J., Li, Y. & Shen, Y. (2014). p-terphenyl O-β-glucuronosides, DNA topoisomerase inhibitors from Streptomyces sp. LZ35ΔgdmAI.

Bioorganic and medicinal chemistry letters 24 (5), doi: 10.1016/j.bmcl.2014.01.037.

7. Deng, J.*, Lu, C.*_{, Li, Y., Li, S. & Shen, Y. (2013). Cuevaenes C-E, New triene}

car-boxylic derivatives from Streptomyces sp. LZ35ΔgdmAI. Beilstein journal of organic

chemistry 10 (1), 858-862, doi: 10.3762/bjoc.10.82.

8. Lu, C.*_{, Li, Y.}*_{, Deng, J.*, Li, S., Shen, Y., Wang, H. & Shen, Y. (2013). Hygrocins}

C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. Journal of natural products 76 (12), 2175–9, doi: 10.1021/np400474s.

9. Schmitt, S.*_{, Montalbán-López, M.}*_{, Peterhoff, D., Deng, J., Wagner, R., Held, M.,}

Kuipers, O. P. & Panke, S. (2019). Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale. Nature chemical biology 15, 437–443, doi: 10.1038/ s41589-019-0250-5.

10. van Heel, A., Kloosterman, T. G., Montalban-Lopez, M., Deng, J., Plt, A., Baudu, B., Hendriks, D., Moll, G. N. & Kuipers, O. P. (2016). Discovery, production and modification of 5 novel lantibiotics using the promiscuous nisin modification ma-chinery. ACS synthetic biology 5(10), 1146–1154, doi: 10.1021/acssynbio.6b00033. 11. Shi, G., Shi, N., Li, Y., Chen, W., Deng, J., Liu, C., Zhu, J., Wang, H. & Shen, Y. (2016).

D-alanylation in the assembly of ansatrienin side chain is catalyzed by a modular NRPS. ACS chemical biology 11(4), 876–881, doi: 10.1021/acschembio.6b00004. 12. Mu, D., Montalban-Lopez, M., Deng, J. & Kuipers, O. P. (2015). Lantibiotic

re-ductase LtnJ substrate selectivity assessed with a collection of nisin derivatives as substrates. Applied and environmental microbiology 81, 3679-3687, doi:10.1128/ AEM.00475-15.

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13. Li, S., Lu, C., Ou, J., Deng, J. & Shen, Y. (2015). Overexpression of Hgc1 Increases the production and diversity of hygrocins in Streptomyces sp. LZ35. RSC advances 5 (102), 83843-83846, doi:10.1039/C5RA12623A.

14. Zhu, J, Chen, W., Li, Y., Deng, J., Zhu, D., Duan, J., Shi, G., Xie, C., Wang, H. & Shen, Y. (2014). Identification and catalytic characterization of a nonribosomal peptide

synthetase-like (NRPS-like) enzyme involved in the biosynthesis of echosides from