University of Groningen
Induced pluripotent stem cells: cell therapy and disease modeling Thiruvalluvan, Arun
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Thiruvalluvan, A. (2018). Induced pluripotent stem cells: cell therapy and disease modeling. University of Groningen.
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Propositions
Accompanying this PhD thesis
Induced pluripotent stem cells: cell therapy and disease modelling
Differentiated cells generated from patient-derived induced pluripotent stem cells (iPSCs) are a valuable tool to dissect pathogenic mechanisms for various genetic disorders and a valuable source of cells for autologous iPSC therapy. (this thesis)
Clinical application of autologous human iPSC-derived oligodendrocyte progenitors (OPCs) in primary progressive multiple sclerosis (MS) patients may provide a potential therapeutic option. (this thesis)
Direct in-vivo reprogramming of reactive astrocytes into myelinating oligodendrocytes could provide an alternative strategy for treatment of MS. (this thesis)
The capacity for re-wiring of the Protein quality control (PQC) system illustrates the versatility of the PQC system to adapt to altered proteomes and underscores the importance of adjusting it to protein homeostasis. (this thesis)
Induction of iPSCs from patient somatic cells will lead to loss of epigenetic signatures that may have been part of a disease-predisposing environment.
Rapid progress in genome editing tools like CRISPR-CAS9 technology will allow genetic manipulation much more efficiently and eventually turn into a possible tool for various genetic diseases which are currently incurable.
Direct lineage conversion holds a high risk of ‘unaltered remaining transcriptome’ which may revert cells back to its original state. (this thesis)
Studies reported that brain-derived neurotrophic factor (BDNF) is significantly elevated in response to exercise. From this perspective, sport activity may support neuronal homeostasis.
Academic internationalization not only results in improvement of international science communication, but also leads to balanced international socio-cultural relationship at multiple levels.
