University of Groningen
Motor function, paratonia and glycation cross-linked in older people
Drenth, Hans
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Publication date: 2018
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Drenth, H. (2018). Motor function, paratonia and glycation cross-linked in older people: Motor function decline and paratonia and their relation with Advanced Glycation End-products. University of Groningen.
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Motor Function, Paratonia and Glycation Cross-linked
in Older People
Motor function decline and paratonia
and their relation with Advanced Glycation End-Products
Hans Drenth
The work presented in this thesis was performed at the Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Applied Sciences, Groningen, the Netherlands, at the Research Institute SHARE of the Groningen Graduate School of Medical Sciences of the University Medical Center Groningen, University of Groningen, The Netherlands and at the Frailty in Ageing research group, Vrije Universiteit Brussel, Brussels, Belgium.
The work described in this thesis was sponsored by Alzheimer Nederland (the Dutch Alzheimer Organisation) and ZuidOostZorg, organisation for Elderly Care, Drachten, the Netherlands.
Cover design Henri Groenewold
Printed by Gildeprint Drukkerijen
ISBN 978-94-034-0798-2 (printed version)
ISBN 978-94-034-0797-5 (electronic version)
Acknowledgments
The printing of this thesis was financially supported by
- Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Applied Sciences, Groningen
- University of Groningen
- Research Institute SHARE, University Medical Center Groningen - University Medical Center Groningen
- Scientific College Physical Therapy (WCF) of the Royal Dutch Society for Physical Therapy (KNGF)
- Alzheimer Nederland (the Dutch Alzheimer Organisation)
- Doctoral School of Life Sciences and Medicine, Vrije Universiteit Brussel - Dutch Society for Geriatric Physical Therapy (NVFG)
© 2018 Hans Drenth, Groningen
All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without the prior written permission of the copyright owner.
Motor function, paratonia and glycation
cross-linked in older people
Motor function decline and paratonia
and their relation with Advanced Glycation End-Products
PhD thesis
to obtain the degree of PhD of the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans
and
to obtain the degree of PhD of Gerontological Sciences Vrije Universiteit Brussel
Double PhD degree
This thesis will be defended in public on Monday 24 September 2018 at 12.45
by
Johannes Christiaan Drenth
born on 29 February 1968 in ‘s-Gravenhage, the Netherlands
Supervisors
Prof. C.P. van der Schans Prof. S.U. Zuidema Prof. I. Bautmans Co-supervisors Dr. J.S.M. Hobbelen Assessment Committee Prof. T. Hortobagyi Prof. D. Beckwée Prof. E. Boulanger Prof. O. Bruyere
TABLE OF CONTENTS
Chapter 1: General introduction 7
Chapter 2: The Contribution of Advanced Glycation End-Product (AGE) 19 Accumulation to the Decline in Motor Function
European Review of Aging and Physical Activity 2016, Mar 4; 13:3.
Chapter 3: Advanced Glycation End-Products are Associated with Physical 45 Activity and Physical Functioning in the Older Population
Journals of Gerontology; Series A Biological Sciences and Medical Sciences 2018, Apr 28.
Chapter 4: Advanced Glycation End-Products are Associated with the 61 Presence and Severity of Paratonia in Early Stage Alzheimer Disease JAMDA 2017, Jul 1; 18(7): 636.e7-636.e12.
Chapter 5: Association between Advanced Glycation End-Products and 79 Functional Performance in Alzheimer’s Disease and Mixed Dementia International Psychogeriatrics 2017, Sep; 29 (9): 1525–1534.
Chapter 6: Psychometric Properties of the MyotonPRO in People with Paratonia 95 Gerontology 2017, Dec 22.
Chapter 7: Summary and General Discussion 119
Samenvatting 134
Dankwoord 138
Curriculum Vitae 140
