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The handle http://hdl.handle.net/1887/20548 holds various files of this Leiden University dissertation.
Author: Klein, Richard Henryk
Title: Minimally invasive methodology for pharmacological research involving children Issue Date: 2013-02-19
minimally invasive methodology for pharmacological research involving
children
minimally invasive methodology for pharmacologic al research involving
children
proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van
Rector Magnificus prof.mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 19 februari 2013, klokke 16.15 uur
door Richard Henryk Klein geboren te Luxemburg
in 1981
7 chapter 1 General introduction
15 chapter 2 Stimulation programs for pediatric drug research – do children really benefit?
33 chapter 3 Levothyroxine for neonates and children with a nasogastric feeding tube: solution for drops superior to tablets
43 chapter 4 Pharmacokinetics and pharmacodynamics of orally administered clonidine
– a model-based approach
65 chapter 5 Repeated administration of a neurocognitive test battery in healthy children
83 chapter 6 Acute effects of methylphenidate in children with adhd on a neurocognitive test battery:
a randomized, placebo controlled trial 111 chapter 7 Evaluation of a bedside device to assess the
activated partial thromboplastin time for heparin monitoring in infants
125 chapter 8 General discussion 137 chapter 9 Summary
143 Samenvatting/Summary in Dutch
149 Curriculum Vitae
15 0 Dankwoord
152 List of Publications
promotiecommissie promotores Prof. dr. J.M. Wit Prof. dr. A.F. Cohen Prof. dr. J. Burggraaf
co-promotor Dr. R.N. Sukhai
overige leden
Prof. dr. H.A. Delemarre – van de Waal
Prof. dr. D. Tibboel (Erasmus Universiteit Rotterdam) Prof. dr. H.J. Guchelaar
Prof. dr. C.A.J. Knibbe
design
Caroline de Lint, Voorburg (caro@delint.nl) acknowledgements
The publication of this thesis was financially supported by the foundation Centre for Human Drug Research (chdr), Leiden, the Netherlands
