The handle http://hdl.handle.net/1887/46172 holds various files of this Leiden University dissertation.
Author: Nuchuchua, O.
Title: Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Issue Date: 2017-02-23
Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Onanong Nuchuchua
อรอนงค์ หนูชูเชือ
Technology Development Agency, Thailand.
ISBN: 978-94-6182-765-4
The book cover was designed by O. Nuchuchua; the picture at the back is a scanning electron microscopy image of lysozyme/trehalose powder obtained by supercritical carbon dioxide spray drying (published in Eur. J. Pharm.
Biopharm., 88 (2014), 919-30)
Printed by Off Page, The Netherlands
Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 23 Februari 2017
klokke 15:00 uur
door
Onanong Nuchuchua Geboren te Bangkok (Thailand)
in 1982
Promotiecommissie
Prof. dr. H. Irth (chair), Universiteit Leiden
Prof. dr. M. Danhof (secretary), Universiteit Leiden Prof. dr. G.F.A. Kersten, Universiteit Leiden
Prof. dr. A. Kros, Universiteit Leiden
Prof. dr. M.J. Cocero Alonso, Universidad de Valladolid, Vallladolid, Spain Prof. dr. W. Friess, Ludwig-Maximilians-Universität, München, Germany
Table of Contents
Page
Chapter 1 1
General introduction
Chapter 2 11
Characterization of particles for drug delivery produced by supercritical carbon dioxide technologies
Chapter 3 75
Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations
Chapter 4 109
Critical processing parameters of carbon dioxide spray drying for the production of dried protein formulations:
a study with myoglobin
Chapter 5 137
The combined effects of carbon dioxide-water interface and pH shift on myoglobin stability
Chapter 6 163
Formulation optimization in supercritical CO2 spray drying for production of dry protein formulations
Chapter 7 191
Summary and perspectives
Nederlandse samenvatting 199
Curriculum vitae 206
List of publications 207
