University of Groningen
Drying Made Easy Kanojia, Gaurav
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Publication date: 2018
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Kanojia, G. (2018). Drying Made Easy: Spray drying a promising technology for the production of stable vaccine and therapeutic protein formulations. University of Groningen.
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Drying Made Easy
Spray Drying A Promising Technology for the
Production of Stable Vaccine and Therapeutic
Protein Formulations
The research presented in the thesis was performed at the research department of Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands. The work was done in collaboration with Department of Pharmaceutical Technology and Biopharmacy of the Uni-versity of Groningen. Financial support for printing was received from Intravacc, UniUni-versity Library and the graduate School of Science and Engineering.
© Copyrights 2018, Gaurav Kanojia. All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means without written permission of the author.
Cover design: Alessia Peviani (www.photogenicgreen.com) Layout: Gaurav Kanojia
Printed by: PrintSupport4U ISBN: 978-94-034-0668-8 (print) ISBN: 978-94-034-0667-1 (digital)
Drying Made Easy
Spray Drying A Promising Technology for the Production of Stable Vaccine and Therapeutic Protein Formulations
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Friday 15 June 2018 at 11.00 hours by
Gaurav Kanojia
born on 11 July 1989 in New Delhi, India
Supervisors
Prof. H.W. Frijlink
Prof. G.F. Kersten
Co-supervisor
Dr. J.P. Amorij
Assessment Committee
Prof. W.J. Quax
Prof. T. de Beer
Dr. D. Christensen
7
Table of contents
Chapter 1 General Introduction
Chapter 2 Developments in the formulation and delivery of spray dried vaccines
Chapter 3 A Design of Experiment approach to predict product and process parameters for a spray dried influenza vaccine
Chapter 4 The effect of formulation on spray dried Sabin
inactivated polio vaccine
Chapter 5 Development of a thermostable spray dried outer
membrane vesicle pertussis vaccine for pulmonary immunization
Chapter 6 The production of a stable Infliximab powder: the
evaluation of spray and freeze-drying for production
Chapter 7 Summary and future perspectives
Appendix Nederlands Samenvatting List of publications Curriculum vitae Acknowledgments 9 17 47 77 99 133 151
