Exploiting HLA-alloreactivity in TCR Gene Therapy of

PTECs and HUVECs were specifically targeted by another alloreac- tive T-cell clone without exogenous peptide loading, suggesting that the lack of recognition of HLA-B*44:02 +

Methods: A varicella zoster virus (VZV) IE62 specific CD8 memory T-cell clone was single cell sorted from a VZV seronegative renal transplant candidate, following response to live

Furthermore, the peptide dependence of the allo-HLA crossreactivity from other viral spe- cific memory T-cells is reinforced by differing potency of the alloreactivity exerted by virus

To confirm that allogeneic cell stimulation resulted in increased viral specific cytolytic ef- fector function, not just proliferation, from the stimulated PBMCs we performed

In this thesis we show that virus specific memory T-cells can demonstrate immediate cytolytic effector function against allogeneic HLA molecules in cytotoxicity assays (25-26)

Hoofdstuk 2 beschrijft een nieuwe techniek voor het isoleren en opkweken van vele identieke T-cellen uit een individuele virusspecifieke T-cel om de immuunreactie tegen allogene

He attended secondary school at Trinity College in Perth and after graduating he started medical training at the University of Western Australia in 1994. He obtained his

EBNA3A Epstein-Barr virus nuclear antigen 3A ELISA Enzyme linked immunosorbent assay ELISPOT Enzyme linked immunosorbent spot FACS Fluorescence-activated cell sorting. FCS