HLA alloreactivity by human viral specific memory T-cells
D'Orsogna, L.J.A.
Citation
D'Orsogna, L. J. A. (2010, December 8). HLA alloreactivity by human viral specific memory T-cells. Retrieved from https://hdl.handle.net/1887/16223
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/16223
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HLA Alloreactivity by Human Viral Specific Memory T-cells
Lloyd J.A. D’Orsogna
Copyright 2010 L.J.A. D’Orsogna, Leiden, the Netherlands HLA alloreactivity by human viral specific memory T-cells
All rights reserved. No part of this publication may be reproduced in any form or by any means, by print, photocopy, scan, electronically or any other means without the permission of the author.
ISBN 978-90-9025808-9
The research described in this thesis was performed at the Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, the Netherlands.
Cover Design and Photo: Chiara Cocco and Nonna Maria Cerasoli Printed by: Gildeprint Drukkerijen - www.gildeprint.nl
Financial support for the publication of this thesis was provided by (in alphabetical order): Astellas Pharma B.V., Beckman Coulter B.V., Europdonor, J.E. Jurriaanse Stichting, National Reference Centre for Histocom- patibility, Nederlandse Transplantatie Vereniging, Novartis Pharma B.V., Pfizer B.V., Roche B.V., U-CyTech Biosciences and VPS Diagnostics
HLA Alloreactivity by Human Viral Specific Memory T-cells
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 8 december 2010
klokke 15:00 uur
door
Lloyd Joseph Andrew D’Orsogna geboren te Perth (Australie)
in 1976
PROMOTIE COMMISSIE (Promotion Committee)
Promotor Prof. Dr. F.H.J. Claas Co-Promotores Prof. Dr. I.I.N. Doxiadis
Dr D.L. Roelen
Overige Leden Prof. Dr. F. Christiansen (University of Western Australia, Perth) Prof. Dr. F. Koning
Prof. Dr. C. van Kooten
Prof. Dr. W. Weimar (Erasmus Universiteit, Rotterdam)
Do not consider it proof just because it is written in books…
Maimonides (1135-1204)
To my past, present and future...
...For my parents because I could not have arrived here without you ...Voor Frans omdat je me deze geweldige kans hebt gegeven ...Per Martina perche tu sei il sole al mio orizzonte
TABLE OF CONTENTS
1. General introduction
2. New tools to monitor the impact of viral infection on the alloreactive T-cell repertoire
Tissue Antigens 2009; 74: 290-297 Appendix to chapter 2:
Detection of allo-HLA crossreactivity by viral specific memory T-cell clones using single HLA transfected K562 cells
Methods in Molecular Biology 2010 (In press)
3. Allo-HLA reactivity of viral specific memory T-cells is common Blood 2010; 115: 3146-3157
4. Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A specific memory T-cells
Transplantation 2010 (In press)
5. Vaccination induced alloreactive memory T-cells in a kidney transplantation candidate
Submitted for publication
6. Alloreactivity from human viral specific memory T-cells Transplant Immunology 2010; 23: 149-155
7. Stimulation of human viral specific cytolytic effector function using allogeneic cell therapy
Manuscript in preparation 8. Summary and general discussion
Nederlandse samenvatting Curriculum vitae List of publications List of abbreviations
9 27
43
53
77
95
111
129
147
163167 173177
