University of Groningen
Brain death and organ donation
Hoeksma, Dane
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2017
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Hoeksma, D. (2017). Brain death and organ donation: Observations and interventions. Rijksuniversiteit
Groningen.
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Brain Death and Organ Donation
Observations and InterventionsBrain Death and Organ Donation
Observations and InterventionsProefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 6 september 2017 om 12.45 uur
door Dane Hoeksma geboren op 14 februari 1988 te Ispingo, Zuid-Afrika Dane Hoeksma PhD-thesis
This PhD-project was financially supported by University Medical Center Groningen
Junior Scientific Masterclass, Faculty of medicine University Of Groningen Research
Institute GUIDE
The printing of this thesis was kindly supported by: University Medical Center Groningen
Research Institute GUIDE Noord-Negentig B.V. Chipsoft B.V.
Cover and invitation: Anne van Erp and Dane Hoeksma
Layout: Rens Dommerholt, Persoonlijk Proefschrift, www.persoonlijkproefschrift.nl Printing: Ipskamp printing, www.ipskampprinting.nl
Copyright: Dane Hoeksma, 2017-06-11 ISBN number: 978-94-028-0690-8
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form without explicit prior permission of the author.
Paranimfen M. Kirschbaum R. Mencke Promotores
Prof. dr. H.G.D. Leuvenink Prof. dr. H. van Goor Beoordelingscommissie Prof. dr. J.L. Hillebrands Prof. dr. D.J. Reijngoud Prof. dr. B. Yard
CONTENTS
Chapter 1 Introduction
Chapter 2 Slow induction of brain death leads to decreased renal function and increased hepatic apoptosis in brain-dead rats
Chapter 3 Quality of donor lung grafts: A comparative study between explosive and gradual brain death induction models in rats Chapter 4 Inadequate anti-oxidative responses in kidneys of brain-dead rats Chapter 5 Differences between kidney and liver perfusion, oxygen
consumption, and metabolism during brain death
Chapter 6 MnTMPyP, a selective superoxide dismutase mimetic, reduces oxidative stress in kidneys of brain-dead rats
Chapter 7 MnTMPyP treatment of brain-dead rats leads to improved renal function during ex vivo reperfusion
Chapter 8 Discussion and future perspectives Chapter 9 English and Dutch summary
List of abbreviations Author affiliations Acknowledgments Biography 9 21 41 55 73 95 115 129 137 146 151 152 157
