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University of Groningen

Donation of kidneys after brain death

van Dullemen, Leon

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

van Dullemen, L. (2017). Donation of kidneys after brain death: Protective proteins, profiles, and treatment

strategies. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Donation of Kidneys after Brain Death

Protective Proteins, Profiles, and Treatment Strategies

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ISBN: 978-94-028-0729-5 Cover design: Jan Willem Deiman

Lay-out: Tara Kinneging, Persoonlijk Proefschrift Printed by: Ipskamp Printing (www.proefschriften.net)

© Copyright: Leon F.A. van Dullemen

All rights reserved. No part of this thesis may be reproduced or transmitted in any form of by any means, electronically or mechanically, including photocopy, recording or any other information storage or retrieval system, without permission in writing from the author, or, when appropriate, of the publishers of the publications. Financial support by the Dutch Kidney Foundation, Junior Scientific Masterclass, and University Medical Center Groningen for the publication of this thesis is gratefully acknowledged.

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Donation of Kidneys after Brain Death

Protective Proteins, Profiles, and Treatment Strategies

Proefschrift 

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

maandag 18 september 2017 om 09.00 uur

door

Leon Frederik Albert van Dullemen 

geboren op 29 juni 1988

te Tilburg

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Promotores

Prof. dr. H.G.D. Leuvenink 

Prof. dr. R.J. Ploeg 

Beoordelingscommissie

Prof. dr. J.L. Hillebrands 

Prof. dr. B. Jespersen 

Prof. dr. R.P.H. Bischoff

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Paranimfen

dr. J.B. Hulshoff

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TABLE OF CONTENTS

Chapter 1.

Introduction and rationale 9

Chapter 2.

Heat shock proteins and their protective role in organ transplantation 21

Chapter 3.

Brain death induces renal expression of heme oxygenase-1 and heat shock

protein-A1A 55

Chapter 4.

The effect of donor pre-treatment with the heat shock protein-inducer

geranylgeranylacetone on brain death-associated inflammation in the kidney 73

Chapter 5.

Donor pre-treatment with Nyk9354, a geranylgeranylacetone derivate, reduces brain death-associated inflammation in the kidney at organ retrieval 93

Chapter 6.

Systematic review for the treatment of deceased organ donors 115

Chapter 7.

Lipid catabolism provides an alternative energy source and compensates for

mitochondrial dysfunction in reperfused rat kidneys after ischaemia 155

Chapter 8.

Deceased donor kidney proteomic profiles correlate with 12-month allograft

function after transplantation 221

Chapter 9.

Impact of pre-analytical factors on the proteome and degradome in human blood 253

Chapter 10.

Discussion and future perspectives 293

Nederlandse samenvatting 301

Author affiliations 305

Dankwoord 307

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