University of Groningen
Donation of kidneys after brain death
van Dullemen, Leon
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Citation for published version (APA):
van Dullemen, L. (2017). Donation of kidneys after brain death: Protective proteins, profiles, and treatment
strategies. Rijksuniversiteit Groningen.
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Donation of Kidneys after Brain Death
Protective Proteins, Profiles, and Treatment Strategies
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ISBN: 978-94-028-0729-5 Cover design: Jan Willem Deiman
Lay-out: Tara Kinneging, Persoonlijk Proefschrift Printed by: Ipskamp Printing (www.proefschriften.net)
© Copyright: Leon F.A. van Dullemen
All rights reserved. No part of this thesis may be reproduced or transmitted in any form of by any means, electronically or mechanically, including photocopy, recording or any other information storage or retrieval system, without permission in writing from the author, or, when appropriate, of the publishers of the publications. Financial support by the Dutch Kidney Foundation, Junior Scientific Masterclass, and University Medical Center Groningen for the publication of this thesis is gratefully acknowledged.
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Donation of Kidneys after Brain Death
Protective Proteins, Profiles, and Treatment Strategies
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 18 september 2017 om 09.00 uur
door
Leon Frederik Albert van Dullemen
geboren op 29 juni 1988
te Tilburg
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Promotores
Prof. dr. H.G.D. Leuvenink
Prof. dr. R.J. Ploeg
Beoordelingscommissie
Prof. dr. J.L. Hillebrands
Prof. dr. B. Jespersen
Prof. dr. R.P.H. Bischoff
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Paranimfen
dr. J.B. Hulshoff
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TABLE OF CONTENTS
Chapter 1.Introduction and rationale 9
Chapter 2.
Heat shock proteins and their protective role in organ transplantation 21
Chapter 3.
Brain death induces renal expression of heme oxygenase-1 and heat shock
protein-A1A 55
Chapter 4.
The effect of donor pre-treatment with the heat shock protein-inducer
geranylgeranylacetone on brain death-associated inflammation in the kidney 73
Chapter 5.
Donor pre-treatment with Nyk9354, a geranylgeranylacetone derivate, reduces brain death-associated inflammation in the kidney at organ retrieval 93
Chapter 6.
Systematic review for the treatment of deceased organ donors 115
Chapter 7.
Lipid catabolism provides an alternative energy source and compensates for
mitochondrial dysfunction in reperfused rat kidneys after ischaemia 155
Chapter 8.
Deceased donor kidney proteomic profiles correlate with 12-month allograft
function after transplantation 221
Chapter 9.
Impact of pre-analytical factors on the proteome and degradome in human blood 253
Chapter 10.
Discussion and future perspectives 293
Nederlandse samenvatting 301
Author affiliations 305
Dankwoord 307
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