University of Groningen
Targeting brain death-induced injury
van Erp, Anne Cornelie
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Publication date: 2018
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van Erp, A. C. (2018). Targeting brain death-induced injury. Rijksuniversiteit Groningen.
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Targeting brain death-induced injury
Anne Cornelie van Erp PhD-thesis
This PhD-project was financially supported by: University Medical Center Groningen
Junior Scientific Masterclass, Faculty of Medicine University of Groningen Research Institute GUIDE The printing of this thesis was kindly supported by: Chipsoft
Noord Negentig
Research Institute GUIDE
University Medical Center Groningen
Financial support by Astellas Pharma B.V., the Dutch Kidney Foundation and the Nederlandse Transplantatie Verening for the publication of this thesis is gratefully acknowledged.
Cover and invitation: Anne van Erp Layout: Anne van Erp
Printing: Printsupport4U Copyright: Anne van Erp, 2018
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system of transmitted in any form without explicit prior permission of the author. ISBN: 9789492597182
Targeting brain death-induced injury
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
Rector Magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 24 oktober 2018 om 16.15 uur
door
Anne Cornelie van Erp
geboren op 22 november 1988 te Hilversum
Promotores Prof. dr. H.G.D. Leuvenink Prof. dr. B. Jespersen Beoordelingscommissie Prof. dr. B.M. Bakker Prof. dr. K. Kotsch Prof. dr. A.J. Moshage
Paranimfen
C.M.A. de Bruijn R.A. Rebolledo
Chapter 1 Introduction 9
Chapter 2 Systematic review on the treatment of deceased organ
donors.
23
Chapter 3 The effect of the β-Human Chorionic
Gonadotropin-related peptide (EA230) on brain death-induced inflammation in rats.
61
Chapter 4 Anti-Apoptotic effects of 3,3’,5-Triiodo-LThyronine in the
liver of brain-dead rats.
83
Chapter 5 Organ-specific responses during brain death: increased
aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys.
105
Chapter 6 Organ-specific metabolic profile during brain death
evaluated using hyperpolarized Magnetic Resonance Imaging: an initial experience.
135
Chapter 7 The crosstalk between ROS and autophagy in the field of
transplantation medicine.
159
Chapter 8 Autophagy is reduced in the liver and kidney following
brain death independent of mTOR activation.
185 Chapter 9 Summary Discussion Future perspectives 211 214 218
Chapter 10 Dutch summary | Nederlandse samenvatting
Authors’ affiliations List of publications Acknowledgements About the author
223 227 228 229 234
