University of Groningen
Oxygenated machine perfusion of donor livers and limbs
Burlage, Laura
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2019
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Burlage, L. (2019). Oxygenated machine perfusion of donor livers and limbs: Studies on endothelial
activation and function.
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OXYGENATED
MACHINE PERFUSION
of
DONOR LIVERS AND LIMBS
Studies on endothelial activation and function
Author:
Laura Cristophie Burlage
Layout and cover design:
James Jardine, www.designyourthesis.com
Printing:
Ridderprint B.V.
ISBN:
978-94-6375-399-9
Copyright © 2019 Laura Cristophie Burlage. All rights reserved. No part of this thesis
may be reproduced, stored in a retrieval system, or transmitted in any form or by any
means, without prior permission of the author.
The printing of this thesis was financially supported by:
University of Groningen, University Medical Center Groningen (UMCG)
Junior Scientific Masterclass (JSM)
Oxygenated Machine Perfusion
of Donor Livers and Limbs
Studies on endothelial activation and function
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties
De openbare verdediging zal plaatsvinden op
maandag 6 mei 2019 om 14.30 uur
door
Laura Cristophie Burlage
geboren op 1 april 1991
te Blaricum
Promotores:
Prof. dr. R.J. Porte
Prof. dr. T. Lisman
Co-promotor:
Dr. K. Uygun
Beoordelingscommissie:
Prof. dr. G. Molema
Prof. dr. P.M.N. Werker
Prof. dr. I.P.J. Alwayn
Paranimfen:
Drs. A.P.M. Matton
Drs. J. Bolt
TABLE OF CONTENTS
Chapter 1 General Introduction and Aims of this Thesis 13
PART A
OXYGENATED MACHINE PERFUSION AND
TRANSPLANTATION OF HUMAN LIVERS
Chapter 2 The Use of Machine Perfusion in Donation after Circulatory Death Liver Transplantation.
Adapted from chapter in: Wu and He (eds). Principles and clinical practice of organ donation after cardiac death (2018, in press)
23
Chapter 3 Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Endothelial Function of Extended Criteria Donor Livers
HPB (Oxford). 2017; 19: 538-546
41
Chapter 4 Opposite Acute Potassium and Sodium Shifts During Transplantation of Hypothermic Machine Perfused Donor Livers
American Journal of Transplantation. 2019; 19: 1061-1071
61
Chapter 5 Normothermic Machine Perfusion of Donor Livers Without the Need for Human Blood Products
Liver Transplantation. 2018; 24: 528–538
83
Chapter 6 Normothermic Machine Perfusion with Cell-Free Blood Substitute Preserves Endothelial Function of Donor Livers
In preparation for submission
103
Chapter 7 Plasma from Patients Undergoing Liver Transplantation Is Resistant to Anticoagulant Activity of Soluble Thrombomodulin (ART-123)
Liver Transplantation 2019; 25: 252-259
121
PART B
OXYGENATED MACHINE PERFUSION AND
TRANSPLANTATION OF LIMBS
Chapter 8 Advances in machine perfusion, organ preservation, and cryobiology: potential impact on vascularized composite allotransplantation
Current Opinions Organ Transplant. 2018; 23: 561-567
141
Chapter 9 Subnormothermic Oxygenated Machine Perfusion of Rodent Limbs
In preparation for submission
PART C
ADDENDUM
Chapter 10 Protocol for Subzero-Non Freezing of Rodent Limbs 179 Chapter 11 Summary, General Discussion & Future Perspectives 193
Chapter 12 Nederlandse samenvatting 207
List of Publications 217
List of Contributing Authors 219
Acknowledgments 225
