University of Groningen
Biomarkers and personalized medicine in heart failure
Tromp, Jasper
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2018
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Tromp, J. (2018). Biomarkers and personalized medicine in heart failure. Rijksuniversiteit Groningen.
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Biomarkers and Personalized Medicine
in Heart Failure
Colofon
Cover design by: Ilse Modder, www.ilsemodder.nl Artwork design by: Steef van Venrooij
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. Further financial support for the printing of this thesis by Olink Proteomics is gratefully acknowledged. Additional financial support for the printing of this thesis was provided by Graduate School of Medical Sciences (GSMS), the University of Groningen and Servier Nederland Farma B.V.
Biomarkers and personalized
medicine in heart failure
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 17 september 2018 om 12.45 uur
door
Jasper Tromp
geboren op 3 januari 1988 te Groningen
Promotores
Prof. dr. P. van der Meer Prof. dr. A.A. Voors
Beoordelingscommissie
Prof. dr. H.P. Brunner-La Rocca Prof. dr. W.H. van Gilst Prof. dr. S.J.L. Bakker
Paranimfen
Dr. M.N. Daams Dhr. S. van Venrooij
TABle oF ConTenTs
Chapter 1 Introduction and Aims 11
Chapter 2 The Fibrosis Marker Syndecan-1 and Outcome in Heart Failure Patients with Reduced and Preserved Ejection Fraction
23 Circulation: Heart Failure. 2014 May;7(3):457-62
Chapter 3 Biomarker Profiles in Heart Failure Patients with Preserved and Reduced Ejection Fraction (COACH)
37 Journal of the American Heart Association. 2017 Mar 30;6(4)
Chapter 4 Biomarker-guided Characterization of Acute Heart Failure Patients with a preserved versus reduced ejection fraction (PROTECT)
65 Journal of the American College of Cardiology: Heart Failure. 2017
Jul;5(7):507-517
Chapter 5 A Network Analysis to Identify Unique Biologic Mechanisms in Heart Failure with a Reduced versus Preserved Ejection Fraction
101 Journal of the American College of Cardiology. 2018 [Accepted]
Chapter 6 Novel Endotypes in Heart Failure: Effects on Guideline-Directed Medical Therapy
131 European Heart Journal. 2018 [Accepted]
Chapter 7 Predicting Heart Failure: One Size Does Not Fit All. 175 European Journal of Heart Failure. 2018 Apr;20(4):674-676
Chapter 8 General discussion and future perspectives 183
Appendixes Dutch Summary | Nederlandse samenvatting 193
Acknowledgements | dankwoord 199
Bibliography 203
