University of Groningen
Increasing the versatility of an ex vivo model in nanosafety studies and fibrosis
Bartucci, Roberta
DOI:
10.33612/diss.119127385
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bartucci, R. (2020). Increasing the versatility of an ex vivo model in nanosafety studies and fibrosis. University of Groningen. https://doi.org/10.33612/diss.119127385
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Stellingen
1. Whether nanomaterials are intended to be used for biomedical applications or enter and distribute into organisms after unintentional exposure, it is pivotal to investigate their potential toxicity in cells and in the organism. (This thesis)
2. Precision-cut tissue slices (PCTS) represent a promising alternative to in vitro models to study nanoparticle behavior and potential toxicity ex vivo using a real piece of tissue. (This thesis)
3. Nanoparticles in ex vivo liver PCTS are accumulated preferentially in Kupffer cells, as is also observed for many nanomaterials in in vivo studies. (This thesis)
4. Exposure conditions and the ageing of nanoparticle dispersions in biological media can affect the final response of liver PCTS to nanoparticles. (This thesis)
5. The 3D ex vivo PCTS model revealed differences in expression of Vanin 1 during fibrosis. (This thesis)
6. If a cluttered desk is a sign of a cluttered mind, of what, then, is an empty desk a sign. (Albert Einstein)
7. Everyone you meet is fighting a battle you know nothing about. Be kind. Always. (Brad Meltzer)
8. Being happy does not mean that everything is perfect. It means that you’ve decided to look beyond the imperfections. (Gerard Way)
