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University of Groningen

Functional and clinical translation of asthma and allergy associated genetic variants in IL33

and IL1RL1

Ketelaar, Marlies

DOI:

10.33612/diss.171580070

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Ketelaar, M. (2021). Functional and clinical translation of asthma and allergy associated genetic variants in

IL33 and IL1RL1. University of Groningen. https://doi.org/10.33612/diss.171580070

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Functional and clinical translation of asthma

and allergy associated genetic variants in

IL33

and

IL1RL1

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Images: Maria E. Ketelaar

Cover: Ilse Modder | www.ilsemodder.nl Lay-out: Ilse Modder | www.ilsemodder.nl Print: Gildeprint | www.gildeprint.nl

© 2021 M.E. Ketelaar. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission in writing from the proprietor.

© 2021 M.E. Ketelaar. Alle rechten voorbehouden. Niets uit deze uitgave mag worden verveelvoudigd, opgeslagen in een geautomatiseerd gegevensbestand, of openbaar gemaakt, in enige vorm of op enigerlei wijze, hetzij elektronisch, mechanisch, door fotokopieën, opnamen, of op enige andere manier, zonder voorafgaande schriftelijke toestemming van de rechthebbende.

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Functional and clinical translation of asthma

and allergy associated genetic variants in

IL33

and

IL1RL1

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op maandag 14 juni 2021 om 11.00 uur

door

Maria Elizabeth Ketelaar

geboren op 20 februari 1986 te Hoogezand-Sappemeer

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Promotores

Prof. dr. G.H. Koppelman Prof. dr. M.C. Nawijn Prof. dr. I. Sayers

Beoordelingscommissie

Prof. dr. H.A.M. Kerstjens

Prof. dr. R.W. Hendriks Prof. dr. I.M. Adcock

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van de weg af zie je meer”

∞

“Next

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Table of Contents

Chapter 1 General Introduction

Translational research: a tailored prescription for patient, doctor and scientist?

PART I "The role of the IL-33/IL1-RL1 pathway in asthma and allergic disorders: current evidence from genetic and clinical studies"

Chapter 2 Decoding asthma: Translating genetic variation in IL33 and

IL1RL1 into disease pathophysiology

Chapter 3 The role of the IL-33/IL-1RL1 axis in mast cell and basophil

activation in allergic disorders

PART II "Functional translation of IL33 and IL1RL1 genotypes into asthma pathophysiology"

Chapter 4 Phenotypic and functional translation of IL33 genetics

in asthma

Chapter 5 Phenotypic and functional translation of IL1RL1 locus poly

morphisms in lung tissue and asthmatic airway epithelium

Chapter 6 Effects of IL-33 on differentiated human Th2 cells stratified

for IL1RL1 asthma risk haplotypes

PART III "Clinical translation of the IL-33/IL-1RL1 pathway in asthma and allergy"

Chapter 7 The challenge of measuring IL-33 in serum using commercial

ELISA: lessons from asthma

Chapter 8 Predictive value of serum sST2 in preschool wheezers for

development of asthma with high FeNO

Chapter 9 IL-1RL1a serum levels and IL1RL1 SNPs in the prediction of

food allergy

PART IV "A bird’s eye view"

Chapter 10 Summary, general discussion and future perspectives

Chapter 11 Dutch summary | Nederlandse samenvatting

References Appendix

Word of thanks | Dankwoord Curriculum vitae of the author

11 25 27 51 61 63 123 171 203 205 213 221 237 239 261 269 289 290 296

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