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VU Research Portal

Improving patient outcomes in colorectal cancer surgery Abis, G.S.A.

2020

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Abis, G. S. A. (2020). Improving patient outcomes in colorectal cancer surgery.

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Download date: 19. Oct. 2021

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IMPROVING PATIENT OUTCOMES IN COLORECTAL CANCER SURGERY | Gabor S.A. Abis

IMPROVING PATIENT OUTCOMES IN

COLORECTAL CANCER SURGERY

Gabor S.A. Abis

UITNODIGING

Voor het bijwonen van de openbare verdediging

van het proefschrift

IMPROVING PATIENT OUTCOMES IN COLORECTAL CANCER

SURGERY

door

GABOR S.A. ABIS Op 17 januari 2020

om 13.45 uur In de Aula van de Vrije Universiteit Amsterdam Boelaan 1105 te Amsterdam Aansluitend bent u van harte welkom op de receptie

PARANIMFEN David Loeza 0614374678 Jesse Kuiper 0644672953 promotiegabor@gmail.com

GABOR S.A. ABIS Gabor S.A. Abis Gerardus Gullaan 16

1217 LN Hilversum gaborabis@gmail.com

0641907523

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Improving patient outcomes in colorectal cancer surgery

Gabor S.A. Abis

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© G.S.A. Abis, 2019

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without permission of the author.

Cover design: G.S.A Abis Original image ID: 639806734

Printing and layout: Sandra Tukker; Ridderprint BV ISBN: 978-94-6375-587-0

Printing of this thesis was financially supported by: Applied Medical, Buon Gusto Ristorante, Commissie Stimulering Wetenschap Spaarne Gasthuis, Erbe Nederland, Fengh Medical, Hollister B.V., JvO Health Consultancy, Stichting Chirurgie en Onderzoek Kennemerland, SWOAHS, TO Pharma Consult

137644_Gabor Abis_BOEK-v2.indb 2 23-10-19 13:32

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VRIJE UNIVERSITEIT

IMPROVING PATIENT OUTCOMES IN COLORECTAL CANCER SURGERY

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad Doctor of Philosophy aan de Vrije Universiteit Amsterdam,

op gezag van de rector magnificus prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie

van de Faculteit der Geneeskunde op vrijdag 17 januari 2020 om 13.45 uur

in de aula van de universiteit, De Boelelaan 1105

door

Gabor Salvatore Anton Abis geboren te Amsterdam

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promotoren: prof.dr. H.J. Bonjer prof.dr. M. van Egmond

copromotoren: dr. S.J. Oosterling dr. H.B.A.C. Stockmann

137644_Gabor Abis_BOEK-v2.indb 4 23-10-19 13:32

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Overige leden promotiecomissie: Prof. dr. G.L. Beets Prof. dr. W.A Bemelman Prof. dr. G. Kazemier Prof. dr. M.C. Vos Prof. dr. J.H.W. de Wilt

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137644_Gabor Abis_BOEK-v2.indb 6 23-10-19 13:32

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“Obstacles don’t have to stop you. If you run into a wall, don’t turn around and give up.

Figure out how to climb it, go through it, or work around it.”– Michael Jordan

Voor mam

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TABLE OF CONTENTS

Chapter 1

Introduction and outline of this thesis 11

Part 1 Improving patient outcome

Chapter 2 19

Laparoscopisch versus open chirurgie voor rectumkanker (COLOR II): Korte termijn uitkomsten van een gerandomiseerde multicenter internationale studie.

G.S.A. Abis, A.A.C. Timmers, M.H.G.M. van der Pas, M.A. Cuesta, P. Neijenhuis, P. Coene, W.A. Bemelman, M.F. Gerhards, H.A. Prins en H.J. Bonjer

Ned Tijdschr Geneeskd. 2014

Chapter 3 31

A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer.

H.J. Bonjer, C.L. Deijen, G.S.A. Abis, M.A. Cuesta, M.H.G.M. van der Pas,

E.S.M. de Lange-de Klerk, A.M. Lacy, W.A. Bemelman, J. Andersson, E. Angenete, J. Rosenberg, A. Fuerst, et al., for the COLOR II Study Group

N Engl J Med 2015 Jul

Chapter 4 51

Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II)

J. Andersson , G.S.A. Abis, M. Gellerstedt, E. Angenete, U. Angerås, M.A. Cuesta, P. Jess, J. Rosenberg, H.J. Bonjer, E. Haglind

Br J Surg. 2014 Jun

Part 2 Reducing complications by altering the patients’ microbiome

Chapter 5 69

Selective decontamination of the digestive tract in gastrointestinal surgery:

a valuable addition to infection prevention? A systematic review.

G.S.A. Abis, H.B.A.C. Stockmann, M. van Egmond, H.J. Bonjer, C.M.

Vandenbroucke-Grauls, S.J. Oosterling J Gastrointest Surg. 2013 Oct

137644_Gabor Abis_BOEK-v2.indb 8 23-10-19 13:32

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Chapter 6 87 Perioperative selective decontamination of the digestive tract (SDD) and standard treatment versus standard treatment alone in elective colorectal cancer patients:

a multicenter randomized clinical trial (SELECT Trial).

G.S.A. Abis, S.J. Oosterling, H.B.A.C. Stockmann, G.J. van der Bij, M. van Egmond, C.M. Vandenbroucke-Grauls, H.J. Bonjer

Dan Med J. 2014 Apr

Chapter 7 99

Selective decontamination of the digestive tract in colorectal cancer surgery G.S.A. Abis, H.B.A.C. Stockmann, H.J. Bonjer, N. van Veenendaal, M.L.M. van Doorn-Schepens, A.E. Budding, J.A. Wilschut, M. van Egmond, S.J. Oosterling, for the SELECT Trial study group

Br J Surg 2019 Feb

Chapter 8 119

The non-selective effect of selective decontamination of the digestive tract on the intestinal microbiota.

M.L.M van Doorn-Schepens, G.S.A. Abis, S.J. Oosterling, M. van Egmond, L. Poort, P.H.M. Savelkoul, A.E. Budding

Submitted

Chapter 9 137

Summary, general discussion & future perspectives

Chapter 10 161

List of publications, dankwoord & curriculum vitae.

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