Hierarchical organization of the circadian timing system
Steensel, M.J. van
Citation
Steensel, M. J. van. (2006, June 21). Hierarchical organization of the circadian timing system.
Retrieved from https://hdl.handle.net/1887/4418
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/4418
Hierarchical Organization of the
Circadian Timing System
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 21 juni 2006
klokke 15.15 uur door
Marry Johanna van Steensel geboren te Rotterdam
PROMOTIECOMMISSIE
Promotor Prof. dr. H.J. Tanke Co-promotor Dr. J.H. Meijer
Referent Prof. dr. G.D. Block (University of Virginia, Charlottesville) Overige leden Prof. dr. A. Dahan
Dr. G.J. Lammers
ISBN-10: 90-9020610-8 ISBN-13: 978-90-9020610-3
The research of this thesis was supported by Leiden University Medical Center Excellent Student Trajectory, Leiden University Medical Center ASPASIA grant, Netherlands Organisation for Scientific Research grant 425-204-02 and National Institutes of Health grant MH62517 to G.D. Block.
Printing of this thesis was financially supported by - Charles River Nederland
- Harlan Nederland
- Nederlandse vereniging voor Slaap-Waak Onderzoek (NSWO)
CONTENTS
Introduction 9
Chapter 1 13
Organization of cell and tissue pacemakers in the circadian timing system; A comparison between species
Chapter 2 73
Differential responses of circadian activity onset and offset following GABA-ergic and opioid receptor activation
Chapter 3 87
The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei
Chapter 4 109
Sleep states alter activity of suprachiasmatic nucleus neurons
Chapter 5 123
Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle
Chapter 6 139
A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock
Summary and Conclusion 161
Samenvatting en Conclusie 165
List of Publications 171
