New fluorescent platinum (II) complexes containing anthracene derivatives as a carrier ligand : synthesis, characterization and in vitro studies

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New fluorescent platinum (II) complexes containing anthracene

derivatives as a carrier ligand : synthesis, characterization and in vitro studies

Marqués Gallego, P.

Citation

Marqués Gallego, P. (2009, September 17). New fluorescent platinum (II) complexes containing anthracene derivatives as a carrier ligand : synthesis, characterization and in vitro studies. Retrieved from https://hdl.handle.net/1887/13999

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13999

Note: To cite this publication please use the final published version (if applicable).

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Stellingen

Behorende bij het proefschrift

New fluorescent platinum(II) complexes containing anthracene derivatives as a carrier ligand.

Synthesis, characterization and in vitro studies

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Highly cytotoxic compounds do not always represent an improvement in the search of new platinum-based anticancer compounds. This thesis

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. An increase in the intracellular accumulation of platinum compounds can be achieved using lipophilic carrier ligands. This thesis

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. Accumulating evidences on the mechanisms of action of new platinum compounds allow gaining insights into the complicate process of their cellular processes. This thesis

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. Relevant modification of the carrier ligand in the cellular medium before the compounds are taken up by the cells, has to be considered for platinum compounds with different carrier ligands than the ammine groups of the cisplatin or carboplatin. This thesis

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. Random synthesis of new platinum compounds is only helpful in the development of the field if their mechanisms of action are also studied.

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. The popular models established several decades ago regarding structure-activity relationships for the platinum compounds are an inaccurate simplification. Current Medicinal Chemistry, 2006, 13, 1337-1357

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. To date, a common “cancer metal-drug resistance” mechanisms has not been reported. Multifactorial mechanisms for cisplatin resistance have been reported, making the task of overcoming this drawback a difficult challenge.

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. An improvement in the time efficiency of cytotoxicity assays in large panels of cancer cell lines may have a huge impact in the research of new antitumor compounds.

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. In the search of an identity outside their house, women are encouraging the men to develop a new identity inside their house.

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. “All of us in the Coca-Cola family wake up each morning knowing that every single one of the world’s 5.6 billion people will get thirsty that day. If we make it impossible for these 5.6 billion people to escape Coca-Cola, then we assure our future success for many years to come.” Coke Annual reports 1993.

The suggestion of solving “thirst” is rather misleading, if we consider that the company used 283 billion liters of water in 2004 in a world where one of five people do not have access to potable water (www.indiaresources.org)

Patricia Marqués Gallego Leiden, 17^th September 2009