Towards a blood stage malaria vaccine, dealing with allelic polymorphism in the vaccine candidate apical membrane antihen 1

Since expression of Serpins may facilitate the immune escape of HLA positive tumors, we next analysed the effect of Serpin expression on survival in cases with normal/partial

The thesis investigates multi-allele vaccine formulation as a strategy for overcoming the effect of allelic polymorphism on immune responses to Plasmodium falciparum

Voor dit onderzoek werden platen gecoat met een van de natuurlijke PfAMA1 varianten FVO, HB3, 3D7 of CAMP, of met een mengsel van antigenen (een mengsel van

His work at BPRC, which is the focus of this dissertation, has been on malaria vaccine formulation strategies based on the polymorphic candidate Plasmodium falciparum

Despite the many allelic variants found in nature, PfAMA1 antigens do have common epitopes, which enable the induction of broad protective responses (this thesis)..

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In