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Cover Page The following handle holds various files of this Leiden University dissertation: http://hdl.handle.net/1887/79946

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The following handle holds various files of this Leiden University dissertation:

http://hdl.handle.net/1887/79946

Author: Skvortsova, A.

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Author: Aleksandrina Skvortsova

Cover design: Aleksandrina Skvortsova, Lolita Dezegher Printing: GVO Drukkers & Vormgevers BV © Copyright Aleksandrina Skvortsova, 2019

All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without written permission from the author.

The research presented in this thesis was carried out at the Health, Medical and

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Placebo Effects and the Endocrine System:

the Role of Oxytocin

Proefschrift

Ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 29 oktober 2019

klokke 15:00 uur

door

Aleksandrina Skvortsova

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Promotor

Prof. Dr. A.W.M. Evers

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Table of Contents:

Chapter 1 Introduction 7

Part I Conditioning of oxytocin and other endocrine responses 25 Chapter 2 Conditioned hormonal responses: a systematic review in animals

and humans 27

Chapter 3 Placebo effects in the neuroendocrine system: conditioning of the

oxytocin responses 63

Chapter 4 Effects of oxytocin administration and conditioned oxytocin on

brain activity: an fMRI study 87

Part II Influencing placebo effects with oxytocin 121 Chapter 5 Enhancing placebo effects in somatic symptoms through

oxytocin 123

Chapter 6 Effects of oxytocin on placebo and nocebo effects in a pain

conditioning paradigm 145

Chapter 7 Summary and General discussion 163

Nederlandse Samenvatting 185

Curriculum Vitae 191

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