Tick, L.W.
Citation
Tick, L. W. (2008, September 24). Diagnosis of venous thrombosis and the post-thrombotic syndrome. Retrieved from https://hdl.handle.net/1887/13115
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13115
Note: To cite this publication please use the final published version (if applicable).
Diagnosis of venous thrombosis
and the post-thrombotic syndrome
Cover design: Renee Bosma Lay out: Yvonne Souverein
Printed by : Gildeprint, Enschede, the Netherlands ISBN: 978-90-71382-39-0
© 2008, L.W. Tick
The study described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHS-98.113)
Diagnosis of venous thrombosis and
the post-thrombotic syndrome
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 24 september 2008
klokke 15.00 uur
door
Lidwine Winnifred Tick geboren te Gouda
in 1972
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
Promotores: Prof. dr F.R. Rosendaal
Prof. dr M.H.H. Kramer, Vrije Universiteit, Amsterdam Co-promotores: Dr C.J.M. Doggen
Dr M.V. Huisman
Referent: Prof. dr M.M. Levi, Universiteit van Amsterdam, Amsterdam Lid: Prof. dr W.R. Faber, Universiteit van Amsterdam, Amsterdam
Aan Renke, Meike, Julia en mijn ouders
Contents
Page
Chapter 1 Introduction 9
Part I – Diagnosis of venous thrombosis
Chapter 2 Practical diagnostic management of patients with clinically suspected deep vein thrombosis by clinical probability test, compression ultrasonography, and D-dimer test.
19
Chapter 3 Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography.
33
Chapter 4 Excluding pulmonary embolism without imaging tests; can our diagnostic algorithm be optimized?
51
Chapter 5 High D-dimer levels increase the likelihood of pulmonary embolism.
65
Part II – The post-thrombotic syndrome
Chapter 6 Risk factors for the post-thrombotic syndrome in patients with a first deep venous thrombosis.
79
Chapter 7 Predictors of the post-thrombotic syndrome with non-invasive venous examinations in patients six weeks after a first episode of deep venous thrombosis.
97
Summary 119
Samenvatting 127
Nawoord 135
Curriculum Vitae 137
List of Publications 139
