• No results found

Molecular detection of intestinal parasites for clinical diagnosis and epidemiology Hove, R.J. ten

N/A
N/A
Protected

Academic year: 2021

Share "Molecular detection of intestinal parasites for clinical diagnosis and epidemiology Hove, R.J. ten"

Copied!
31
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)Molecular detection of intestinal parasites for clinical diagnosis and epidemiology Hove, R.J. ten. Citation Hove, R. J. ten. (2009, October 1). Molecular detection of intestinal parasites for clinical diagnosis and epidemiology. Retrieved from https://hdl.handle.net/1887/14031 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/14031. Note: To cite this publication please use the final published version (if applicable)..

(2) . 

(3) .     !"##$%&'( )&&)*  +  ,*&-.  &&/0  *  (  0)0  (  ()')&12)34533$-36  7  *!"#86%9/0:+00:(&-0:))00 0):;/(()'012

(4) 0:<35-4 +2(0= 

(5) "<664%:&0:'*0:00&0)0( :&1 +

(6) 045<<3-8 &90 *20/,- &)/  )/):2 "<668% !0)0*

(7)  (>:0>/'(0)'0:>4<8()&'5?&0(0:>:)-)0()0/00!=0/*"##3##4%1/2)()0!<453-3<3   @2   "<66%   @:  >  (  />  >  )/  &.    '0 '&>*5

(8) 

(9) )0/*1@

(10) 0185$3-$$ *&/   "#88%  

(11) )/  />>0  (  /    ?&0  (  )) ')&('0)()012

(12) 0435##-#46 *&/"###%9-'0+0*00(

(13)  ++> ,*&-.&&/0*--A0=00B+&##8-):##$1  0.* '$5-$ *&/"<66% 9)0

(14) ((.0=>&01@/& >01  +  05       :00'5CC'/1/D01>5$C'>C=01(CE F)0

(15) 0:GC=:'C(:'C

(16) /)0C<3C=/

(17) /)0C<3-1 *&/"<66%/()0/H)(')0>*.00:( (-'0+

(18)  0>00--<661 0 .* '35#$ 0=

(19) ,7>*!)9 /& "<66%  0+0/>(&0:0')5'')0+0/*(4<<'0012@+ <53<-3$ 0&**.0 *A&,= *"<668% :) '0+0'0'005

(20) 

(21)  1@'0

(22) )3#54#3-4#.

(23) 4. >':*. ,2=):&  

(24) 0):( 2 "#$% =&+0  

(25) 

(26)      0::/&)0/&>&1@ =)@' *><54<4 *9!F09B:+/

(27) !!):&07//,@ &9  ,B D,/

(28) 7&.2  /=  "<66%  /& ''&+//)&&/0*I&D50:&')0( 7)-()0

(29) 7>0*'0/0127835$- *7:+7/097!&&

(30)  +0!7).7. *

(31)  7&.2"<66%@:'+)(0::/&''&+/ )+?+>D-.:>:-.''/01=)2()0!3454#1 D* "#4<%=):0&(0:)+?12534#-38< *@:&   *2 ):>B"<664% &0:()0 0:0'(D>'0=1@ =)@' *> 665$<-$4 ((2  !/(:/2"#$#%J*'0'5'+)0: 00& )&'(<0>&0:(00)0K1B@F): . 335<<<#-<<33 02 =):,!   /0  "<66% @:>/ 0?'& " :&#6%F/F)0+**&(0:>/ 

(32) 

(33)  "=): $$%')()0>/)0(

(34) 

(35) 

(36) "9.#88%0: ))0>/(

(37) 

(38) ')()0>&&&12

(39) 0#58<4-8<8 000  ,-=/+@0/0 2I = B+ 2  "##% ++> ''):0&>&0(;/0*))&)>*1) + 85-$$ =0F  =20:&-+!

(40) = & "<666% !0)0;/000(:'00+/ B ()():)*()0 +/12)3$53<-3 * "#84%@:)*0>*'0:>*():0&(0:(&>0 0)01A+0*(0:0D01 0:*2.= ) >=/. !&0!  0,

(41) 2"<664% =-0&00:&0:()05)0):/:.D&1)0 3485<-3<.

(42) >':*. 8. .      B  !0,    ):  2   I).  A   "<66<%   &'  ( /0(/))0>(0)0( 

(43) 

(44)   ()1 &2 @' *>48536-36      D  A  7DF  22  ,>- .     7:(  2   "<66% *)'/0.1&>()0!53- &2/ B/

(45) @!:@B>L@77   !2).@9 . +2 @): "<66<%  -0&

(46)  (0)0((00(     

(47)        

(48)    ()  &'1  2    ) 653-8 >> :=*02= "<664%

(49) ')0+*('0) ()00+&&>012@+353$- 00/?2=):07/0 7). 7+0@!&* / 7 &'  72 "<664% 0>*/0)&((+(00*0:0')1 ):04454<4$ 00/?277)./ 7 &'  72"<668%9+(00*0:0')5>0)')0( 0:>0'))01)$45$-< 00/?27> 7/ 7). 7+0@7 &'  72 "<664% &'00*&(+5 ))>)(0/0'00/>00&012()0<533#3 /D! =0/(( -

(50) 0  ):2=0 ==/&&

(51)  B =  =/''0'*   :D0:   . 

(52) 9  "<668%  00&0  ( =0>*()05)DD':*)--0>/+*1 & 2<651-$   2     @!  >  =  '  9   9  2   "<664%    0 ''):00:0+'0?&01()0!<5#8<-#8$ 0& 0: />  !',

(53) "###% >:'+)(    

(54)    D  D0:  (/  >0*'  0:0  ((  (&  0: 0(:/&1

(55) 0>*$"

(56) 0%58-3 /D    @&  22   &  2   "###%   /0  )>  (  ): 0/>:&(&0:0')50')0+0/*123$54$-4# M:

(57) & 27!> &&  (&!2&  /& "<668%B -=0 )/01 /00):'6563-3.

(58) $. >':*. /F0F+''0=>2  /F 2 /2 7DF22 '')0&'&00(0*)0-0&

(59)  (0: 0)0((/'0,0&'1)()0' ))  =  @:&'    )/):  2   =&0:  7   "<66%   A+> 

(60)  '&>*1@

(61) 01<536-38  22   >2!)&0 2 > "<66%. -0&

(62)  &'+0)0(  

(63) 

(64) ()0)&'D0: )/0//>(-))0+>D1()0!00 *)35-6 22

(65) :=9>:20/+  2

(66) :  >

(67) :. /:(

(68) 2+:/0 @ ).00 . ): D0.D.!

(69) */? + ."<66$%=+ &D):1B1>1213$5$$$-$## /= * B>D2 *B200:B/=.B=./=  >>  "<664% A>'00*0:'0()0&> &&>0(/> /012@+35<33-<3# >.2

(70) 0> )=29 =):D0,! F2> 9=

(71) /'.A

(72) > D.*/! =0>   "###% 

(73)       

(74)  ()0'0)/0 '00D0::@,1()0!<$53-3< 0  -

(75) 0 

(76) )09 02  B/,"<663% '    7,/  /0  D0:  :/&  &&/())*  +/5  )) ):)0,01 &2@' *>4#5<8-<<< :):  +2"<663%D0*'&0 7C !='001 @' 

(77) 0#8=/''58-8$ :0/    >  !  0     =+     "<666%   @:  >  00/  ( ):0&0)01 )0@'1885- &0

(78) !   "<666% @=5)&'/0'>&00&0 >>>1)#548-4# 9 0+-/F' F2 /0: "##$%)) .()0(:!/0):0+5);/)('0'-0+ :0:+)1@'0 0:35$#4-#63 :9 "##4%&>>()0/5B/>'1B/> /0.54-4$ := 

(79) ):!"<66% &'( 70&D''):0 7 '+012()0!#53#-3#31.

(80) >':*. #. ):  >0  > "<66%000>*5)>0 &>&00&0(/0)&12 003#5<63-< 00     "<663%   &'0)    '0(  (  &)/  *  0  '0 '&>*1@

(81) 01#534-3$ 0B  :  

(82) /0:2="<666%@:'*(:/&>000 &)'1 &2@' *>435<-<8 ?9 "<66<% 0*( /&

(83) 0>*1) +5#-4< &'0  !@   "<664%  

(84) +0+  ):&0:'*    :/&  :&0:5 )0/(0:&0:)/>)00+05&/(:0: '('>&&&>1 0:>,0B0*1 !)> ',"#8%B/&( 0:()(()0):1 &2@' *><5<38-<< !  /F      "#$$%   !>0)  !B  &'()0    '0  (  0:  /+ '01

(85) 0@*5<#3-<# !);!7)/*2

(86) );/0=:D!2!'*   *"###%@: '&>*  (    )0  ()/  (  &?  

(87) 

(88)          

(89) 

(90)    

(91)  ()0  /  0:  H)    /H    0:  =>  + =>1@'0 0:5-6 !0  ='& 

(92) 0.0 2 7F 2+ / 9 0  +!/*:+@

(93)  "<66% =''/0-):0 0/*    >000    0:  B0:5  ))    0>*1  &  2  ' 5444-48 !0'&0.+/DB0  +!/*:+ "<66% 0000>')0)@:B0:1&>()0 !85$<-# !0'&0.+/DB7F2 +!/*:+ "<66)%0>*(>0000>')0)@:B0:1 ()0!335<$6-<$$ !>FI: & 0,='&@@:&):. ):@ 0:     "<66%I0)'00(   

(94) 12 )3#5#-## !'0:'0   ):-

(95) 0+> . + 

(96)    >    "#$%   ))/)  (    D  &)'5   

(97)  1>11'10:0)*0(:/&'00D0: !=12

(98) 0,3<5<6-<.

(99) 6. >':*. !="<66%)'5&>>''0/0)()0:/& &1 )0@'#54-84 !:>9&  !((  "#$3% !*-0-*+0)) :*0:&  ( >>  ?)0   /* ):0&   0:  =/1   @'  

(100) 0885$8-# !> &&222 ;/2  >/* "###% 9-'0+ /00D0:0: ?

(101) =')@

(102)  ,*&&&/*12 )385$<-$3 >7DF22

(103)  7 "<66%J/0.(& !/0):(&*N0')/?')0**K1B@F): .$5$36-$3 :D  @      7DF  22  ID    @>    :&    *  ! &):  @    @ 

(104) &    

(105) 0     "<664%   00 &)':'00()0D0::/&&&/())*+/  0:'12'121()01!1#5364-36 > ! =,.*    *  "##4%   !*-0-* >>  )/0 (/)0/0    

(106) 

(107)   

(108) ()00'0&')01 &2@' *> 53#-3< '*2 *

(109) B !A:2 =2. !0/'!).9 

(110) 0.  002  =&0: @9  "<66% !0)0(:' &'? +/!B  >0&')&*>:0*)

(111)  (0?0)0/>0:L/). >B 

(112) / 0#46&0:12)3#5<<33-<<34 '*2A:2 =/).D0=

(113) 29700 2!>). B  00  2  ).  9    =&0:  @9   "<664%   -0& 

(114)     )) &)>*5  '')0  (    /0  0*  00>1     )   + #54-<4 90 OO/@

(115) 02 /000:  2 "<668% =+ 0>*)0)0-00'005)00/+D12 ()05$-<8 90:>2"##8%@:&)/'0:>(>12

(116) 0 00 B/0<58#-$$ 90:>2 "<664%@0&0'0(0:)0(00'0,1B0 

(117) )0 00 '03534- 9*    "<66%   '&>*  ( 

(118)  5  0&  0)0   0()0102

(119) 036536-3<<.

(120) >':*. . 9& 0, 

(121) >> "##%9&>0):0&.()0(0:0&( 7102=@! !=534$-38< 9&  

(122) >> "##3%!>0)0):;/):0&)01 +D1 )0@'<5<6-<<6 9&   

(123) >>    0,     >-    "##%  9&  >0 ):0&1BD):>(&>'')0+1@' >85=<=1 9& ID>>=0  !0): "#$% !>0)+/( )0'*))00&0: 

(124) 

(125)    5;/000+ )&'(0:0):;/1@'&

(126) 03<5<3-<4 9D).    "<664%   0  ()0/  --)/  0:*    )>  0 :0*E=))335688-6$ 9="<666%()0*'0,&&/)&'&:01&0 D/,#=/''5#-4< 9P+   

(127) ),,    2  2  /  =   /     "<664%   /&  () 0*'&5'&>*)01 +

(128) 04548-<< 90 =0.!B00!2  .2 "<668% 0* >0)0):;/(  ')1) +<65-3< 9/=>/* 07 >/?2

(129) =(0!/9 2"##$% )' / 0   

(130)  ()0  ')/ ( 0+H:1/2)()0!8583-8 9,  /  =,>   0& 

(131)  !:  7 90.:/    "##4% A+0?<0(0:>( 

(132) 

(133)   ()0'00D0:0: );/&&/())**&1 ):

(134) 0:<656<3-6< 9,     M    "###%   )/  0):;/  (  0)0  ') ((00    ':*>0)  *  (  &)'1    )  + <5<3-<$ 9&! ,.*

(135) 9.@  +=/>9*02=

(136) * 

(137)    0  =   "<664%   =')0/&  (      0  0  ')  ( ?'/&>0/0+1B>235#-36 ,2/0 , 99*=B+F 

(138) ,. B2=+ 2  >/"##$%!0)0(  

(139) 0D :/&  &&/())*  +/->0+  '00  D0:  ):)  :  * '*&):)0/'*')&+D1()0! <853#-3#$.

(140) <. >':*. )  =   "<66<%   0*  0()0  (  0:  &)'1  2    ) 65$#<-#6 )  =   =:&,/     "##8%   +/0  (    &&/*  .0  ",*& &&/*    )0  (/))%  (  0)0  (      

(141)   :/&()')&12)35<4-<# )2):&2 7 2"##% 

(142) '00 D0:0+H:1=)2()0!<85- 0=/'/00&>.*D! :( *2 2):>B2  0  "<66<% I0)')( 

(143)   '+00: 0:'0) 7-()0'00@:1 @'

(144) 0#458#8$6< 0:&7 2).@9 "#$8%  >0/0/*(*&'0&0))( '0:>),*&&(  

(145)  = (28<544#-48< D@ / 

(146) , ))Q="<668%)/):)0,0 (:/&0(

(147) (&0:'1 )0@'6<5#<-## 2>>

(148)  @

(149) "<66$%)/"

(150)  -%>0)( D-/)'0-(-)00>1)0*00 ::=!0: = !=:00':**!2 !

(151) "<666%

(152)  0)0(  050>0>0>)')>(&/0)'* B >1 

(153) 5$-$#  "#<%:,(0:(&>00)012=/0: ()<5 & !9.:/

(154)   0:9  "<664% !+'&0( 0&'*&):)0(;/000( 

(155) 

(156)   

(157) !B 1& 0D/,6533-34 &,       0,    /+     

(158)   =)>    

(159) ,     "##% ''0/0)-''0/0)'0 7-'0+>0+'00 D0::@,1@'

(160) 0456#- >&    "<663%   &>>  )/  (  0+H  :5 

(161)    

(162) 

(163) 

(164) &)'1/()0! '544-83 :&9"#% +)(0:>( 

(165) ()01 &2@' *>5#-4 > ',-7B

(166) &*& =&0:  @0 "<66$% 0:'>>0(0:

(167)   &/0)/>0*''01 '&()0345<83-<8$.

(168) >':*. 3. +!"##4% /&0>*1 +

(169) 03$5<-36# *

(170) &?2 0 "<664%  /&):0&1)0 34$564-$ /!2"##$% />0+)0->:0:'&1&> ()0!5<-6 /  00>/*

(171)  !/=

(172) )0= @/ 2 "###% 00&)'))/>0D0'0)'0 00D0:&*)':0&(01@'004$54##-868 /0  "##8% *'0'5&>>:>:*()0/0:01&> ()0!35-8 /0    />:  2 & B  2  "##6%  !:   +'  +'>)/05&>0/')00>0>1 +()0!< =/''5=-=6 /:/.9/. =0(( "<668% ):>000+:0:12 @+5<6-<6$      0D>:0  

(173)   "<66%   A  (    ,*&  &&/*    0 &00:0*,&/0'0')&(0+0)0(  12)3#58-88 ;/    *  =      =0/'  =    !   /'0     "<66%   &> ()0:>:12()0!#<5<8-<83 2 "#$<% J &'0):)(0:&00()*'0'()K1 I070&<#53<-3<8 >-  =F0 

(174) >> F09 ):02:0//&D B ),

(175)   /= 0, 9& "##4%9&>0 ):0&  "9 =%5  0:'  0D  >*)>)    :0'0:>) (>1 )0@'4<5<8-<48 D0"<666%*)')*05+D()/>0:/0.( )*)'0:##61()0!3566-68 00 . B>"##% D&*0?&0)*0 0)0'0:>)00'0,E &2@' *>3534-3#   2   "<663%   A0>  D&H  000/  0D  D(  0>   I&D1/ 0:>$56-$.

(176) . >':*. & >0 &' +'9"##$%:)0,0 (  

(177)  *  '*&-):-)0  (>'0>1 

(178) 0   $5868-8 &    .  @   "<66%   /&  >5  >0*'  .  (()   ))*&'0&0>*102

(179) 035$<<-$<4 '.!  /,-@!D

(180) 0:

(181)  >/2 "<66%!)/)/ )050:():1 &2@' *>83544#-48 '.  =   ):  9  /,-@    & 

(182)    >  0: 

(183)   "<66$% !)/)/  ):))  ):0&    0):&1    B    )  =) 345-< R& ' =/02   S "<66% 0-* &0  (  0:  '+)    /  ))  (  ''1   

(184)   ''1()0:/&0:B))/0102

(185) 0 35338-34 0,

(186) 2*/?! 9D). /&2=):==):2! =+"<668% 0(>)00')1B>23856$-6<8 /0.    +      2  B:/,  2

(187) @  

(188) >     "<66% '&>*(

(189)  ''1 

(190) *(&170

(191) 06<53-48 F& .B@ :  *:"<66%&'+&00:0)00( :>))0:/&0')&*'-0&

(192)  *12 )3548-4<< 2).@9 0:&7 =&F  "#$% ='&>)0/*(0* '00:,*&&(0&:0*0)1)0584-8# 20      2   /    "<664%    +  -0& 

(193)   0  0)0     

(194) (0-+/>0D12)5448-48 2.@

(195) * R):@ B0:/(0 !"##4%+/0(0>-)'0/ ,*&&&/*(0)0(  

(196)  0&'1/2 )()0!58<-8 2>2 T"<663% +/0(&)/>0)0(0:0)0 ((00(:/&-'0:>)

(197)  ''12/.*0) 6=/''5<-8 2(  =2D= "##% '/)0*()> *0&(>&0>()0+>12)<#5836-83.

(198) >':*. . 2:    22  .    "<66%  &>>  (&  )/0*5 >) ))>0)')0(   

(199) 1) +85386 2   = "#%=0/:/&0>*11 )&'( 0:(())*(>*?&0(()/(/1 &2

(200) 0:<5-$ 2  2  ',    :;/0  =

(201)   B  2        "<66%   =/+*  (  )) 0*')0)('0)1()0!3$=/''35=#$-=<6< 2>/2+:0+

(202) + 02  +!2  +  /D  9  =)://& @   "<666%   +/0  ( /0&0 /))  ) ?0)0+)('')0 7B @1@(/65$8-$8 2>D/0D  = 

(203) /0'0'    :.    D.  @     @   "<668% ':>)&)/):)0,0(

(204) 

(205)  )*0(&'00 @:1 &2@' *>88568-< /,/ :0/7@7+0B &9 "<66%  

(206)  

(207) 

(208)  '00D0:0+H:5)'0+D12@+ 54-43  

(209)   /0     =&0:    "<668%   0  0&  (  '0, '05DD+D(/0.0120 0:5-3$ '  /D0

(210) "<668%()0D0: 70')()0/1 1 &0:)(/>)0+'0:>1()0!5<-<<6 0F     =     "###%   !:    !=    0:    (  :>:*  )0+ 00+0:'*1()0!<$586-86 0.@=):= 002  = 

(211) )' "<66%+/0( 

(212)   C*'0'/&  '  *   

(213) =')@ C

(214)   &)'0  *  (  0)0  (   

(215)  ()')&12)3#5<3-< 0,B:+  

(216) >2"#8<% &'+)(;/000+00:).&0):;/=):0&&1 +00'=

(217) /53#8-66 0,D.-):  =          R):  @       "##4%   !)0 &'()0    ')  0&0  (  &)'  !B  (&  0 ')&1@'0 0:5383-38$ / 

(218) 00>=:0:

(219) =/F=> )!&*= . '> "<66$%@:>00)0&&/&/5&'000&0 ( 7/)'00*)*0&12 '&&/8853<-6.

(220) 4. >':*.  7DF22!>-I0&=@+:/0

(221) 0 

(222) &@"<663%+>(&0:)(   

(223)   &>'00'0>D0::F ..0:'1 @ =)@' *>#8536-368   2   A0,>  2   "<66$%   (())*  (  )/0  />  >0  -0&00 :&0:()05*0&0)+D&0-*12  <##5#38-#$ 

(224)  B/0&@"<66%

(225) 

(226)  

(227) 0:&&/)&'&

(228) '/01) +85<6$-<8  M:/ =0,!>:(=0 0: "<66% 9/* /0&0/)))?0)05>B 

(229) /1:&85<-<4 F09 D,/B:+/

(230) !//,@ &

(231) ,B9   /  =   "<66%   '  &'?  +/  0*'  <  '+)  (  '&) ''0    /  I&D  D&5  )0  D0:  0:  ?/* 0&00()01 ): *)00<8<548-83 F0  9  /D  B  B:+/ 

(232) !  ,  B  D,/     

(233)   &   =+.    //,  @  9     /  =   "<66$%   9&  >0 ):0&-((0>0?/*0&005>00): +>):>)0(>0 

(234) 

(235)     &0* )-)00/*&)/I&D1@'0 0:356#8 F09B:+/

(236) ! &//,@,B D,/

(237) =+. 9   /= "<664% )00D>0):0& 7/I&DD&1 !=<65#3-466 F0  9  B:+/ 

(238) !  /D  B  ,  B  &    //,  @  9     /= "<66$%

(239) +0(>*)>))0)0>>0* '0):*)::0-):0&00&01 &2@' *>8#58#-$3 F09B:+/

(240) !//,@ & D,/

(241) /DB ,B9   /=  "<66% =&'))&(00(>0  

(242) 

(243)       ()0    /  I&D  D&1 &121@'11 *>18<53-3# F09

(244) >>  >-   ):02=F0 :0//&D B /= 0, 9&  "##4% 9&>0):0& /0 

(245) 

(246)     1)'0>)(>D& /D1 )0@'4<5<3#-<   !   "<66<%   L/0()0  />  -0& 

(247)   0):>*5  '')0   &001@11$5<8-<46.

(248) >':*. 8. ''2  : 9&= 7&. "<663%&'(/0&0 &//)))?0)0&0:(0)0(0+/ B 121 1)533<-334 ).  B

(249)  

(250) 0    9  @  =00.    =):&0,    !', 

(251)  

(252) ,.  B2 ):0  =):00/2"##8%=')-')()0()0(&)' 000'*')&*0:'*&):)01/2 )()0!4534#-384 :    /:   

(253) .0    /'0    BD&  !  =    &     /0     "<66$%   

(254)  &>  ))  '00   &.(00(&&0,):1@1 1=)1@'11 *>6<58$-8< .  /0 "<663%@:>/(: 0&0(&0/'/:0D##<<6661/ 0:> $5#8-<6 &    /):  !   >     "<666%   =):0&    0+ &)1/2 56-6       =+     "###%   00  '0  (  &  :)  7'0++/B0:,D0:'0)/()0 

(255) 

(256)   *#<3    

(257)  2'' !#$1&0D /,#54-43 .  9!:& 0:& B):  /0

(258) +0 =  /*"<668%-)00/*(+&0)()0(/)> )*'0'1/2'&<<5$6-$ &&

(259) 29D).  A0,>2 "<664%  /'0(/))50>0( >)00'))0'>&&1@

(260) 0<<533-3< . ).: DB

(261) : ) 00>

(262) )& 70 9)& ', @:&'2! @2  >>!  "<668% /0/0T+<161(&0)<35<#8-<#$ :*9  "<663% 9)00/0>00:))/)(&>>()0/ !1 B/5<$-<48 :*9  !/:&2!"<668%&>>()0/!5@/< 1='>

(263) /:>&'*1 ? @& 

(264) 0 2"##%!B ;/)(0:')()0)0( *'0'/&'+/&*0:'*&):)01  &2@' *> 54$$-4#.

(265) $. >':*.  @     !   )/ !

(266)   "<666%   0):  !B  ;/)  (  :/& ):0&50:)/000/102

(267) 0365<$3-<#6 *+==//>/> > :+0:D.-

(268) 0&0

(269) '>2 B>@ />0:"<66%@&(  

(270) >0*' @:':>1 &2@' *>8356-68 *+==//>/>=/'/00&>.'>2

(271) 0&0

(272)  />0:    "<664%   0()0  (  >0*'  (   

(273)  (&  0 &'(&:/&&&/())*+/-()0'00@:12 )5366-366 > ."<66$%9-+/0(>00'00(> (  

(274) 

(275)   

(276) *0)0>))/0>)0:)0>" %/ D&)0:'1

(277) 05- >"##$%0/>0000&0>/(I&D1 31 I&D5B!@

(278) 1 /0):

(279) !

(280)  :22= ((&=0D.= . &0/)

(281)  A/& "<66%)'+)(/.)*0 +0  )*0.  +    &  (&  

(282) 

(283)      -()0 +/12()0!#543#-48 D0:D0

(284)   7 0  ):>B2"<66% 000'00: &&/)&'&1/0'()0/!$5<8-3 >/*!+9=(0!/9 2"##$%!0&0(0*'(   

(285)  0  0  (&  '00  D0:  00 &)'12)345$$<-$$ >/*    =(0    !/  9     2   "<66%   +)  (  ((0   

(286)  >0*'    '00  D0:    D0:/0  :/& &&/())*+/()012)3#5<48<-<48 T&7=0+@ 0/9 0 "<664%  0*'(   

(287)    &&&   

(288) 0/>1  2  /.*0  )  3  =/'' 5=4-4 ',-7, @/0 0

(289) B+F 9*=  >/ "###% )'0+D0::(&0:0')12@+ 45<<3-<<8.

(290) >':*. #. ',->* 9*=@2  >/"<66<%00 &)'  /  0   

(291)    *  :/& &&/())*+/-->0+'00(&7>='1()0!35#$#< />:  ='0,= "##%!>(:&0:12  3#5##8-666 /0(* *02= "<66<%=>*':)/0 0:>&>&0(0>*-&)1 &2@'  *>4458#-8< *  ! 

(292) >    A0D.    

(293) .  !   "<66%   @')  ()0/ 5!>0)(0:+'>D1B0 +)<5<3-<6 ).*"<66% -0&

(294)  0:&)>*0*11)1()01 65#6-<< .  @   I0  2   "<66%   !>0)  +0>    0:'/0)  '0  ( >1?'0'+0>!/>653-# .@ I02! +F.2@ 

(295) &  "##8% =0+0*( &))'*+/,*&&&/*0:0*>(>1 /2)()0!454-4# .@ I02 

(296) & "##%JA0&0(00'0, )/(:(&*')0)K1B@F): .3#53<-3<8 .@ I020.&'2 

(297) &  "##% &'((: )//&)00)0))(&'+0')&(> (00'0,()01/2)()0!5684-6$ : /0>  "<666% +/0((/,*&&&/*(0: 0)0(  0>0')&1/2)()0 !#5$-$8 ) @:& !/'0   0/,,"<66$%

(298) :*'()0 *&5    &>>  >  ()0/  1  @   =)  @'    *> 6<53-3$ 0  2"##3%/0'0?&0(+'00 ((->0+/012)3536-36 0:   !',

(299) "<66%I0)'00(0:&)'1 ) +$5<3- */

(300)  )&).!"<66%0+0>0?/*0&00()0 "=@%0'+0 7()01/$5<#-31.

(301) 46. >':*. )/):2 &

(302) ,-!,= B): "<666%)/'&>) *  (  *'0'/&  ''1    0:  A0  >&5  /0  (  >0*'> 

(303)   ''186()&'(&:/&6()&' (&+0).&12)3$53#$-3##6 00  2  0   

(304) ):    =(0    !/  9     2   "<663% !+'&0  (    -0&  '*&-):-)0  *  (  ;/000+ 0)0  (   

(305)  !B    0  ')&  (& &&/)&'&  '00  D0:  00  &)'1  2  ()0  ! $854#-8 00  2  0    =(0    >/*    !/  9     2   "<663% !+'&0(-0&

(306)  *(;/000+0)0(  

(307) 

(308) !B 12)56-3 .&' + & =):.2 "<668%=&/0/0)0( (+((0!B 0>0*-0&@;&

(309)  />0: ):>:0*)$65 '')0+&)/>0)1270:5<6- */?! "<66% UB>)0V/0/)>/))W):> ''0/0(()0/)01)03453$6-3$3  

(310)   D    *:(     * 

(311)   "<663%   0)  +0*  D0:  0: &':>)')  

(312) 

(313)  00:'0:0>1()0 0+35<#-3$ 

(314)  >=>  @:&'  "<66% &>>0):>(0: 0)0    >0)  ):)0,0  (  '0,  '01  @ 

(315) 0 <536-34 

(316) *:(  D  &&' *

(317)  "##4% )/ >0)  *  (  

(318) 

(319)  0  0  0:  >/0&0  :*> )/1

(320) 0>*<5-<  

(321)   @:&'    "<663%  

(322)    -,5  ()0   ()0E()0 0+35<33-< 0&!7. 

(323) 0*027 02 O>/ 9 "##8% &'?'*)):

(324)  :0()5 !     &12)35##-##$ >2 01"<66%>+()0(0::/&'0 

(325) 

(326)   

(327) 1)53$$#-3#6<.

(328) >':*. 4. >  A 

(329) 0    !D*    9  !   ):     @:&'     "##$% &'  ( 

(330)     &))'*  (  0)0  ( 

(331)      :/&()')&5)@12)345##-##$ >A009! @:&' "##8%!((000D :/&&0(

(332)   />!B ;/)> )0

(333)  *12

(334) 0$35$<-$36 >  A   @:&'    "##$%   )/  0)0  (  '0)  '0,1

(335) 0>*8=/''5=83-$15=83-=$ >  A   @:&'    "##$%  

(336)   0)0  ( 

(337)  5  @:  D* (DE

(338) 0>*@*5<-< />

(339) 

(340) !=  :="###%@:)0(()0+(00>( 0:00&0(00'0&&>01B>2365883-88# M    .    9S0.:/    =,>    !:  7   9,     "<666% !0)0( 

(341) 

(342)   *'*&):)0/>'& &-//0& B ;/)1/'2/())>* ()0/!#543-43 M    .    &'    90.:/    =,>     9,     "<66% !0)0(&)'0+D0::12)3#5436-43< />0:=//>/>B>@ &'/

(343)  ./ *+="<66% =':>'00(  

(344) *&'0&0)):12 )583-84 B,  !*:& : >D  

(345) + "##3% @:(0:0')&/00*?&0(00 '012

(346) )08584-8$ B0 "<66<%)+>*0&127<53-< B.= >*@! : "<668% )'()0 '+0:0:*''&12)5<$-<$4 B0&!

(347) . 2>!0.-&&  + @ "<66%!0)00()0(  

(348)   ')0/')&*

(349)  ((0:*,012 )3546-4.

(350) 4<. >':*. > *0* !2 &: = ! ,.::   0>  9  .*  !   7DF  22  +  !&  2   +  :/0     "<66$% '')0())/0>-)0:)-0>" %0'00-0&

(351)   )&'  D0:  &))'*  (  0:  0)0  (  

(352) 

(353)        /&'(& :1 @'

(354) 06<54<-433 .:/* 

(355)  "<66%   @+H : / 0  00  '0,1  ()0 ! 3356- .:/*

(356)  "<668% @+H:D>:012 00=/'' 5=<6-=<3 +9 ==7!) +)09 @;/0 9>9>  9&  "<664%  )()+)):0&&>D&(&0D (0:-0,D0:&)  

(357) 

(358)   

(359) 1 @'

(360) 0665#- 0: +* @2:9 !DF/ ./0:   * 2 "<666%=*&)00&0(?/*0&00/)0:''0 (  )0  7  ()0  00/0  0  0:      /  @,1  != 5<#-381

(361) '27  2: "#$#% @0&0'':*?( 

(362) 

(363)   ()0'00D0:0:);/&&/())**&1B>2 3<656-68

(364) )    2  2:  !  B    "<664%    -0& 

(365)   &0:  ( ;/0(*>+

(366) 

(367) >>/>0:(00*0)')>( &!B 1 ''+)8<58$4-8$8<

(368)   &  2   !> 

(369)   "#4%   !>  (  0>*5  &'0)  ( &H&0:1 &2!>!145$##-#6

(370) O,X +

(371) ,=7>7Y;/,97)=02 =&' =Y):,  2"<66$%

(372) +)(0'0 >0*'>( 

(373) /+):1

(374) 0 635#-4

(375) 0

(376) :&/ /&2 =>.@"#84%90/(' ))/0&(;/0(*>  

(377) 

(378)       >>/&'1 / 0:>15#-4<

(379) 0*  9   "##$%   '&>)  0/*  ( 

(380)     0 J))0K('(& &*1()0<458-6.

(381) >':*. 43.

(382) ,.B*-9=&==+ / D!0):   ! "###% BD 

(383)   >0*' 7-()0'1 &>()0!5-#

(384) >>    D/    =    ):0  2  0,     9&    "##$% =):0&(0:D'/)0+0)0D0:/0>>?)0/1 &2 @' *>#58$<-8$3

(385) >> D/>7 R''!!):@0, 9& "<666% 9&>0):0&(0:D>00)05'+))0&0*0:@,12()0!$5<6-<3

(386) >>    =:  =  7  ).    =D    0,     9&    "<66% !>  (  >0  )+)  ):0&5  )&'  (  )*0>) :0'0:>)'0>)?&01 &2@' *>45<33-<34

(387) >>    9&    "<66%   9&  >0  ):0&5  ()0   :*'0:1 )0@'8#5#3-<6

(388) & "<66%):'0>0:1=*0?1

(389) & 0.&'2 7DF2"###%!>0.+

(390) ()01B@F)::&<546-4

(391) 0!-B0   "<66<%!0)0*'*&):)0(  

(392) 

(393)   

(394) !B :/&/&()1 &2@' *>44584<

(395) 0    +    0, B  !-B0        "<663%   &' (   '*&):)00:0-0,0):;/(>>()0D0:  

(396) 

(397)   

(398) 1 &2@' *>4$54<-44

(399) /0 =0  )Z-* @=/0 )X2   ,Y,-:, 2 "<664%*)'5'0/)/0.);/ /0&12@+ 3533-338. ))/0

(400) 9/):O >&*

(401) 002:/.@@00  

(402) '2 "<66$%

(403) )(   

(404)  )0D0:00)))'00 D0:):):+0> 7)0 01 &2@' *>8#58#-$6. &9I/ 

(405)  & &, . )   T&,"###%@:(()0((&(?00:'*&):)0 ):)0,0(  

(406)  1@ =)@' *>#3533-334.

(407) 4. >':*. */!)9/7  /07,  7+  

(408)   

(409) *  9   "##$%   0()0  (   

(410) 

(411)   0+D0:):):*')()

(412)  &'()012)345386. 02 0 @:&' "<66<%00D>0*' (

(413) :102

(414) 03<5<<#-<3. =2/00! 9.  "<666% )/0):;/())>0) +>*12

(415) 0:356<-64. / !+ !+/?&0:9 ):  "#$#% 

(416) +)( +>):0&)/* 

(417) 

(418)     &)+> B>1@ =)@' *>$358#8. 0((  "#% @:?'&00&(:/&00'0, '011 )*0>+)'/1 &2 *>#5<6#-<<6. ):02"<663%@:&')0():&0:'*&0*/0):0&1 )0@'$454-$3. *!  D> "#4% @:+/((&-0:))00(() )*0+12

(419) 0:#58-84.  0,D.-):= ):@"##8%+)(0:?0)( >0)*0)00(  

(420) 1

(421) 0 $35486-48<. >/,- ,  2  /0-)     0-=):,     "##4%   = '+)(

(422)  ()0):00>*) )0=&)"='%0/('(&0:1/2'& <5<#-<#.   2  /((&  !   ))    "<66<%   .    )0  (  D0 )*'0'19=)1 +<453-<3 =9

(423) .BD  D

(424) .  /*  "<66<%  0*'>(   

(425)   !='00(&0:0:D0(>12()0 53#-< =:>/ 2 +    

(426)  =  0 @ 0  92 ' =      &,-/    "<66$%   0  0D  0:  ')  (  *&'0&    0: 

(427) >0*'1/2)()0!<85$-$3 =.  (! =0((==):(=2 >/):   @/ ):  "#$$% 

(428) &-)0,*&0)&'()0(!B D0:0:&0!B  '*&1=))<3#5$8-#.

(429) >':*. 4. =& 2I:/2 &,-!/0 

(430) = *=  =):/02 "<66%

(431) +)(()0/&>00*'0 ):1

(432) 0)6$546$-4< =.+Y) ,Z.+Y! /7 "<66$% 90'0(  . 

(433) ()0'>(&0:,): '/)170

Referenties

GERELATEERDE DOCUMENTEN

Deze scriptie onderscheidt zich van eerdere werken omdat het specifiek voor de Nederlandse situatie onderzoekt hoe geldovermakingen van migranten en dus hun economische banden met

Waar respondenten aangeven de hoogte van de afvalstoffenheffing van belang te vinden en melden graag meer mogelijkheden tot subsidie hierop te zien, vormt dit voor de

Since expression of Serpins may facilitate the immune escape of HLA positive tumors, we next analysed the effect of Serpin expression on survival in cases with normal/partial

Deze begrippen zijn, waaronder GDA, open geformuleerd en kunnen hierdoor verschillend worden geïnterpreteerd door de AIVD, haar toezichthouders en de politiek.. Deze begrippen

In 2015 startte Mi-lan als promovenda bij het instituut Pedagogische Wetenschappen op een internationaal longitudinaal onderzoeksproject naar de overgang van zwangerschap

Detection of amyloid plaques in mouse models of Alzheimer’s disease by magnetic resonance imaging.. Apostolova

More precisely, an upper bound for the variance of the test statistic R N ∗ is realized by the one-dimensional Moore-Rayleigh null hypothesis, whose distribution is similar to the

The results on simulated data show that the MR3 outperforms permutation tests on Hotelling’s T 2 test (pHT2) in the detection of difference of mean in small sample sizes, since the