University of Groningen
The blueprint of microglia
Zhang, Xiaoming
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zhang, X. (2018). The blueprint of microglia: Epigenetic regulation of microglia phenotypes. Rijksuniversiteit
Groningen.
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Propositions accompanying the dissertation The Blueprint of Microglia
- Epigenetic regulation of microglia phenotypes-
1. Peripheral inflammation permanently alters microglia by epigenetic rewiring (this thesis).
2. Systemic LPS results in endotoxin tolerance where β-glucan induces trained immunity in microglia in vivo (this thesis).
3. Neuronal genotoxic stress primes microglia while genotoxic stress in microglia induces apoptosis but not priming (partially in this thesis). 4. Intricate interactions between the metabolome and epigenome are
necessary for endotoxin tolerance in microglia (this thesis and Arts et al, 2016).
5. Research in cell biology is a wonderful adventure to a mysterious and fantastic world, which deserves great interests, investment, wisdom, patience, sacrifice, and collaboration.
6. “The hardest problems of pure and applied science can only be solved by the open collaboration of the world-wide scientific community – Kenneth G. Wilson”. Collaboration in science makes the research more efficient, integrated, and beneficial.
7. “An investment in knowledge pays the best interest – Benjamin Franklin” & “Education is the most powerful weapon which you can use to change the world – Nelson Mandela”. This is true for a person, a family, a society, and a country.
8. Man’s nature at birth is good. A society of fraternity, equality, liberty, and harmony without discrimination, greed, and violence will become true.
