• No results found

Gibbs sampling procedureMissing data D

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "Gibbs sampling procedureMissing data D"

Copied!
1
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 1 pagina )

Hele tekst

(1)

Gibbs sampling procedure

Missing data DR

Model parameters  Model structure Cm

genes

…

experiments

Biclustering genes / experiments?

Transpose the matrix

Discretize the data6

Model with multinomial likelihood and Dirichlet prior6 Model with Gaussian

likelihood and Wishart prior5

Microarray data matrix

Sample C1 from its full conditional distribution

Sample Cm from its full conditional distribution

…

Sample 1 from its full conditional distribution5,6

Sample v from its full conditional distribution5,6

…

Sample DR[1] from its full conditional distribution

Sample DR[n] from its full conditional distribution

Collect the samples

Defined number of iterations reached?

C1 = … = Cm = 0?

N

DR[1] = … = DR[n] = 0?

N

Initialization

Maximum number of initializations

reached?

N

Y

Y

Y

Mask the obtained bicluster, and set the number of initializations to 0.

Final determination of the bicluster:

Monte Carlo integration – PME estimates for the posterior

distribution of Cm, , and DR

Y End

1 2

3

Referenties

Download het nu ( DOC - 1 pagina - 46.00 KB )

GERELATEERDE DOCUMENTEN

Gibbs sampling for motif finding

ACGCGGTGTGCGTTTGACGA ACGGTTACGCGACGTTTGGT ACGTGCGGTGTACGTGTACG ACGGAGTTTGCGGGACGCGT ACGCGCGTGACGTACGCGTG AGACGCGTGCGCGCGGACGC ACGGGCGTGCGCGCGTCGCG

Gibbs biclustering of microarray data

 For gene biclustering, remove the data of the genes from the current bicluster.  Search for a

HK07 – Les 10 Expectation-Maximization en Gibbs Sampling voor Motief-Ontdekking

 Integrated Clustering, Upstream sequence retrieval, and motif

Gibbs sampling for microarray data analysis

Bayesian models for microarray data analysis and Gibbs sampling 4.1 Basic ideas of Bayesian methods: posterior  likelihood * prior 4.2 Applying Bayesian models on microarray

Gibbs sampling for microarray data analysis

limitation of the traditional methods, and an overview of popular clustering algorithms applied for microarray data analysis3. 1.4 Biclusterin algorithms: the

GIBBS SAMPLING ON BAYESIAN MODELS FOR BICLUSTERING MICROARRAY DATA

Putting together data obtained by from microarray experiments under different experimen- tal conditions (which can be different tissues, time points, or environmental

Applications of Gibbs sampling in bioinformatics

Because Gibbs sampling has become the method-of-choice for the motif-finding problem in DNA sequence analysis, and our idea of applying Gibbs sampling to the biclustering of

Query-driven biclustering of microarray data by Gibbs sampling

So in a complex compendium, where it may not be clear which microar- ray conditions are truly most relevant to the biological question at hand, the question becomes “which genes