Development of a vernix caseosa substitute : a novel strategy to improve skin barrier function and repair

Only on the cell surfaces (insert Fig. 4B), lipid lamellae could be observed occasionally. This is different from the lipids in SC, which are organized in very well defined stacks

Investigation of the lipid organization by Fourier transform infrared spectroscopy and small-angle X-ray diffraction revealed a more disordered state of lipids at 37°C than at

The outermost layer of the skin, the stratum corneum, comprises the main barrier function between body and environment. The stratum corneum features a highly structured

The barrier lipids have less influence, since SSLM prepared with a twofold increased barrier lipid content did not affect the endothermal transition (Fig. When comparing the observed

Furthermore, the increase of the initial water content of the microgels from 50% to 80% (w/w) (i.e. biofilm B2c) slowed down the complete water release to 140 h. This formulation

Development of a vernix caseosa substitute : a novel strategy to improve skin barrier function and repair..

As the barrier repair model severe #3 is merely appropriate to study the effect of formulations in the initial recovery period due to its fast recovery, the effect of VC treatment

Typically, these studies are combined with monitoring the skin barrier (recovery) by measuring the transepidermal water loss (TEWL). To gain more insight into the mechanism of