Cover Page
The handle http://hdl.handle.net/1887/61393 holds various files of this Leiden University dissertation
Author: Cuijpers, Sabine
Title: Regulation of cell cycle progression by small ubiquitin-like modifiers
Date: 2018-04-05
Sabine A.G. Cuijpers
Regulation of cell cycle progression by small ubiquitin-like modifiers
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Cover: A representation of an intercellular bridge during cytokinesis, the final connection between the newly formed daughter cells. Microtubules and the midbody are visualized in a U2OS cell by using antibodies against tubulin (red) and KIF4A (green). Images obtained and adapted by Dr. Daphne M. van Elsland and Sabine A.G. Cuijpers.
Layout: wenz iD || Wendy Schoneveld
Printing: ProefschriftMaken || www.proefschriftmaken.nl ISBN: 978-94-6295-882-1
Copyright 2018 by Sabine A.G. Cuijpers, Leiden, The Netherlands. All rights reserved.
Copyright of the individual chapters lies with the authors, except for chapters 2, 6 and 7.
No part of this thesis may be reproduced, digitalized or transmitted in any form, by any means, electronic or mechanical, including photocopying, recording or by any information storage or retrieval system, without prior permission from the author.
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 5 april 2018
klokke 15.00 uur door
Sabine A.G. Cuijpers geboren te Oosterhout (NB)
in 1990
Regulation of cell cycle progression by small ubiquitin-like modifiers
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Promotor Prof. dr. P. ten Dijke
Co-promotor Dr. A.C.O. Vertegaal Promotiecommissie Prof. dr. M. Tijsterman Prof. dr. J.J.C. Neefjes
Prof. dr. S.M.A. Lens, Universitair Medisch Centrum Utrecht Prof. dr. T.K. Sixma, Nederlands Kanker Instituut Amsterdam
Reis ver, drink wijn,
denk na, lach hard, duik diep, kom terug Spinvis (2011)
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TABLE OF CONTENTS
CHAPTER 1 General introduction 11
CHAPTER 2 Guiding mitotic progression by crosstalk between post-translational modifications
Trends in Biochemical Sciences. Accepted for publication
41
CHAPTER 3 SUMO targets the APC/C to regulate transition from metaphase to anaphase
Nature Communications. Accepted for publication
67
CHAPTER 4 Chromokinesin KIF4A teams up with stathmin 1 to regulate abscission in a SUMO-dependent manner
Journal of Cell Biology. Under revision
103
CHAPTER 5 SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites
EMBO Reports. 2015;16(4):512-9
135
CHAPTER 6 c-Myc is targeted to the proteasome for degradation in a
SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
Cell Cycle. 2015;14(12):1859-72
153
CHAPTER 7 Converging SUMO and ubiquitin signaling: improved methodology identifies co-modified target proteins
Molecular and Cellular Proteomics. 2017;16(12):2281-2295
177
CHAPTER 8 General discussion 213
APPENDIX Dutch summary (Nederlandse samenvatting) Curriculum Vitae
List of publications
Acknowledgements (Dankwoord)
233 241 243 245
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