Regulation of hypoxia-inducible factors by small ubiquitin-like modifiers
Hagen, M. van
Citation
Hagen, M. van. (2010, May 26). Regulation of hypoxia-inducible factors by small ubiquitin- like modifiers. Retrieved from https://hdl.handle.net/1887/15552
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Curriculum Vitae
Martijn van Hagen was born on the 8th of february 1979 in Delft, the Netherlands. After graduating from the Sint Maartenscollege Voorburg in 1997 he went on to obtain a Bachellor degree in Biochemistry from the Hogeschool Rotterdam in 2002. A research internship at the University of Oxford, in the lab of Dr. Rosangela Da Silva, inspired him to pursue a career in science. To that end, after entering the lab of Prof. Dr. Hans Tanke in 2002 as a research technician, he managed to obtain a position as a PhD student. In January 2005 he formally started his PhD training in Molecular and Cellular Biology under supervision of Dr. Alfred Vertegaal.
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157 List of publications
1. van Hagen M., Vertegaal A.C.O. (2010) Small Ubiquitin-like Modifiers and other Ubiquitin-like Proteins. Vidal, CJ (ed.), Protein reviews series: Post-translational modifications in health and disease. (2010) Springer Business and media.
2: van Hagen M., Vertegaal A.C.O. (submitted) Inhibition of Hypoxia-Inducible Factor- 1α by conjugation of Small Ubiquitin-like Modifier-1 and -2 to a Lysine in a Non- Consensus Modification Site.
3: Schimmel J., Larsen K.M., Matic I., van Hagen M., Cox J., Mann M., Andersen J.S.
and Vertegaal A.C.O. (2008) The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle. Mol. Cell Proteomics, 7, 2107-2122.
4: van Hagen M., Overmeer R.M., Abolvardi S.S. and Vertegaal A.C.O. (2010) RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia- Inducible Factor-2α. Nucleic Acids Res., 38, 1922-1931.
5: Matic I., van Hagen M., Schimmel J., Macek B., Ogg S.C., Tatham M.H., Hay R.T., Lamond A.I., Mann M. and Vertegaal A.C.O. (2008) In vivo identification of human Small Ubiquitin-like Modifier polymerization sites by high accuracy mass
spectrometry and an in vitro to in vivo strategy. Mol. Cell Proteomics, 7, 132-144.
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