Cover Page
The handle http://hdl.handle.net/1887/66111 holds various files of this Leiden University
dissertation.
Author: Streit, S.R.
Title: Perspectives on treating hypertension in old age : the burden of polypharmacy, risks
of treatment and GPs’ treatment probability
Issue Date: 2018-09-25
Perspectives on treating hypertension in old age – The burden of
polypharmacy, risks of treatment and GPs’ treatment probability
Sven R. Streit
Perspectives on treating hypertension in old age – The burden of polypharmacy, risks of treat- ment and GPs’ treatment probability
ISBN: 978-94-6361-126-8
Cover design: Optima, Rotterdam NL Layout and Printing: Optima, Rotterdam NL
© Sven R. Streit, 2018
This publication is protected by international copyright law. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the author.
Perspectives on treating hypertension in old age – The burden of polypharmacy, risks of treatment and GPs’ treatment probability
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag, 25 september 2018
klokke 10.00 uur
door
Sven Raphael Streit Geboren te Aarau, Zwitserland,
in 1980
Promotor
Prof.dr. J. Gussekloo Co-promotor Dr. R.K.E. Poortvliet Leden promotiecommissie Prof.dr R.C. van der Mast
Dr. E.P. Moll van Charante, Universiteit van Amsterdam Prof.dr. N. Rodondi, Universiteit van Bern, Zwitserland Prof.dr. M. Muller, Vrije Universiteit Amsterdam
The research project presented in this thesis was funded by grants from the Swiss National Science Foundation (P2BEP3_165353), and the Gottfried and Julia Bangerter-Rhyner Foun- dation, Switzerland.
Contents
Chapter 1 General introduction 7
Chapter 2 Polypharmacy and specific comorbidities in university primary care settings
21
Chapter 3 Lower blood pressure during antihypertensive treatment is
associated with higher all-cause mortality and accelerated cognitive decline in the oldest-old – data from the Leiden 85-plus study
43
Chapter 4 Association of low systolic blood pressure under antihypertensive treatment and cognition in old age
61
Chapter 5 Variation in GP decisions on antihypertensive treatment in oldest- old and frail individuals across 29 countries
81
Chapter 6 Burden of cardiovascular disease across 29 countries and GPs’
decision to treat hypertension in oldest-old
97
Chapter 7 General discussion 113
Chapter 8 summary 127
Chapter 9 nederlandse samenvatting (summary in Dutch) 135
Deutsche Zusammenfassung (summary in German) 143
Bibliography 149
Acknowledgements 153
Curriculum vitae 155
