Cover Page The handle http://hdl.handle.net/1887/66888 holds various files of this Leiden University dissertation. Author: Mastboom, M.J.L. Title: Tenosynovial giant cell tumours Issue Date: 2018-11-13

Current TGCT incidence is based on 1 single US-county study in 1980, with an incidence of 9 and 2 per million person-year in localized- (including digits) and diffuse-

Specimens of all localized- and diffuse-TGCT cases showed a scattered, tissue infiltrating distribution of CSF1 expressing cells (figure 2).. Corresponding to the landscape

In part one, six MR parameters were defined by field-experts to assess disease extension on MR images: type of TGCT, articular involvement, cartilage-covered bone invasion,

To verify that diffuse-type women with increased TGCT-symptoms during pregnancy were comparable with diffuse-type women not pregnant during TGCT in the patient support

Data were derived from three sources: (1) a systematic review on TGCT in children, seeking sources published between 1990 and 2016, included 17 heterogeneous, small case-series;

In a subgroup analysis of patients with primary disease treated in a tertiary centre, the greatest risk for first local recurrence was associated with tumour size ≥5 cm

In a subgroup analysis of therapy naïve patients with diffuse- TGCT affecting the knee, surgical technique was not found to be associated with first local recurrence

Complete remission 2 (4) Partial response 15 (27) Stable disease 36 (65) Progressive disease 2 (4) Overall response rate 17 (31) Rate of disease control 53 (96) Symptomatic response