Citation
Oosterhout, M. van. (2008, November 19). Pathological features of rheumatoid synovitis in the context of therapeutic interventions and clinical settings. Retrieved from
https://hdl.handle.net/1887/13337
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13337
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Pathological features of rheumatoid synovitis in the context of therapeutic interventions and clinical settings
Maikel van Oosterhout
Pathological features of rheumatoid synovitis in the context of therapeutic interventions and clinical settings
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. dr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 19 november 2008 klokke 13.45 uur
door
Maikel van Oosterhout geboren te Zundert
in 1973
Referent: Prof. Dr. P.P.Tak (Universiteit van Amsterdam)
Overige leden: Prof. Dr. R.R.P. de Vries
Prof. Dr. D.M.F.M. van der Heijde
Dr. I. M. Bajema
Dr. R.E.M. Toes
Omslag: Menivano
Layout en Drukwerk: www.gratisproefschriftopmaken.nl
ISBN: 978-90-8891-070-8
De druk van dit proefschrift werd financieel ondersteund door:
het Reumafonds, Abbott B.V., Wyett Pharmaceuticals B.V. en Schering-Plough B.V.
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Contents
Chapter 1 General Introduction 9
Chapter 2 Superior effect of arthroscopic lavage compared to needle aspiration in the treatment of inflammatory arthritis of the knee 29
Chapter 3 Comparison of efficacy of arthroscopic lavage plus administration of corticosteroid, arthroscopic lavage plus administration of placebo, and joint aspiration plus administration of corticosteroid in inflammatory arthritis of the knee. A randomized controlled trial. 47
Chapter 4 Clinical efficacy of infliximab plus methotrexate in DMARD-naive and DMARD-refractory RA-patients is associated with decreased synovial expression of TNFD and IL-18 but not CXCL-12 65
Chapter 5 High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities 85
Chapter 6 Synovial differences between anti-CCP positive and anti-CCP negative
rheumatoid arthritis 95
Chapter 7 Changes in synovial inflammation over time in rheumatoid arthritis 113
Chapter 8 Summary and general discussion 125
Chapter 9 Samenvatting 135
Curriculum vitae 143
Dankwoord 144
Publicaties 146
