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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/13147.
CD8+ T cells (cytotoxic T lymphocytes, CTL) recognize MHC class I molecules bearing short peptides present on all nucleated cells and CD4+ T cells (T helper cells) interact via
Now that we have shown that p53-specific Th1 responses can be efficiently induced in p53+/+ C57BL/6 mice by immunization with synthetic peptides comprising the identified
A) Full-length coding sequences of frameshift-mutated genes that lack stop codons were fused in frame to a sequence encoding the H-2Kb-restricted CD8+ T-cell epitope
Supplemental material.. Negative selection prevents development of p53 reactive CD8+ T cells. Total lymphocytes from thymus and spleen of mice with indicated genetic backgrounds
Nevertheless, even in case of T-cell tolerance, passive cell therapy by adoptive T cell transfer in this last antigen scenario could also lead to a robust T-cell response since
Pas als T-cellen deze antigenen niet herkennen kunnen ze volledig differentiëren en een functionele T-cel receptor en CD8 of CD4 moleculen tot expressie brengen zodat ze de
Pieters aan het Instute for Risk Assessment Sciences (IRAS) van de Universiteit Utrecht, werd zij in 2000 voor een jaar gekozen tot student-bestuurslid van de faculteit
