Development of the sinus venosus myocardium from the posterior second heart field : implications for sinoatrial and atrioventricular mode development
Vicente Steijn, R.
Citation
Vicente Steijn, R. (2011, June 16). Development of the sinus venosus myocardium from the posterior second heart field : implications for sinoatrial and atrioventricular mode
development. Retrieved from https://hdl.handle.net/1887/17712
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17712
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Development of the sinus venosus myocardium from the posterior second heart field
Implications for sinoatrial and atrioventricular node development
Rebecca Vicente Steijn
© Rebecca Vicente Steijn, Den Haag
All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without written permission of the author.
ISBN nr: 978-94-6108-162-9
Cover: Barcelona design by Monste Breda Biada Layout: Tiny Wouters
Printed by Gildeprint Drukkerijen- www.gildeprint.nl
The work presented in this thesis was carried out at the Department of Anatomy and Embryology of the Leiden University Medical Center.
Development of the sinus venosus myocardium from the posterior second heart field
Implications for sinoatrial and atrioventricular node development
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van de Rector Maginificus prof.mr. P.F.van der Heijden,
volgens het besluit van het College voor Promoties te verdedigen op donderdag 16 juni 2011
klokke 11.15 uur
door
Rebecca Vicente Steijn geboren te Barcelona, Spanje
in 1983
Promotiecommissie
Promotores: Prof. dr. A.C. Gittenberger-de Groot Prof. dr. R.E. Poelmann
Co-promotor: Dr. M.R.M. Jongbloed
Overige leden: Prof. dr. A van der Laarse Prof. dr. N.A. Blom
Prof. dr. R.N.W. Hauer (Universitair Medisch Centrum Utrecht)
Financial support of the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The realization of this thesis was also financially supported by Boston Scientific B.V, Sorin Group Nederland N.V. and Toshiba Medical Systems Nederland.
Contents
1 General introduction 6
2 Podoplanin deficient mice show a RhoA related hypoplasia 26 of the sinus venosus myocardium including the sinoatrial node
Developmental Dynamics 2009;238:183–193
3 Electrical activation of sinus venosus myocardium and 48 expression patterns of RhoA and Isl-1 in the chick embryo
J Cardiovasc Electrophysiol 2010;21:1284-1292
4 Platelet-derived growth factor is involved in the differentiation 68 of second heart field-derived cardiac structures in chicken
embryos
Developmental Dynamics 2009;238:2658-2669
5 Expression of Id2 in the second heart field and cardiac 92 defects in Id2 knockout mice
Submitted for publication
6 The funny current channel HCN4 delineates the developing 118 cardiac conduction system in the chicken heart
Heart Rhythm 2011 in press
7 Development of the sinoatrial and atrioventricular node 138 in the avian embryo: morphological and electrophysiological
changes during maturation Submitted for publication
8 General discussion 166
Summary 186
Samenvatting 192
List of publications 198
Curriculum Vitae 202
Dankwoord 206
