Mechanistic studies on transcutaneous vaccine delivery : microneedles, nanoparticles and adjuvants
Bal, S.M.
Citation
Bal, S. M. (2011, February 15). Mechanistic studies on transcutaneous vaccine delivery : microneedles, nanoparticles and adjuvants. Retrieved from
https://hdl.handle.net/1887/16485
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Stellingen
Behorende bij het proefschrift
Mechanistic studies on transcutaneous subunit vaccine delivery Microneedles, nanoparticles and adjuvants
1. Microneedle pre-treatment enables painless delivery of compounds into the skin.
This thesis 2. Although nanoparticles are suitable to ensure concomitant delivery of antigen and adjuvant to dendritic cells, smaller antigen-adjuvant conjugates are more suitable for transcutaneous vaccination.
This thesis 3. Because of the intrinsic adjuvanticity of N-trimethyl chitosan (TMC), TMC-based nanoparticles
can induce a more potent immune response than liposomes.
This thesis 4. In pre-clinical studies on transport into the skin the limitations of the animal model form a
difficult barrier to overcome.
This thesis 5. “A different perception or interest in the administration routes seems to exist between
pharmaceutically and immunologically oriented scientists working in the field of vaccines.”
P. Johansen et al. J Control Release 2010 148 (1)56-62 6. “Although studies of delivery systems have often been separated from those of adjuvants, it is
now clear that the basis for adjuvant performance may lie with its particulate nature.”
A.C. Rice-Ficht et al. Curr Opin Microbiol 2010 13 (1) 106-12 7. “The prospect of elimination of several hundred million cases of dehydrating diarrhea in infants and hundreds of thousands of deaths with a vaccine that is needle-free, stable at room temperature, and easy to administer has led to a vigorous program to develop a patch and pretreatment regimen suitable for such an application.”
G.M. Glenn et al. Infect Immun 2007 75(5) 2163-70 8. “During the first half of the 19th century the cowpox vaccine against smallpox infection was
maintained by arm-to-arm transfer of the virus.”
P.D. Ellner Infection 1998 26(5) 263-9 9. “If you’re a pre-doc before getting a PhD and a post-doc afterwards, that means you’re only a
“doc” for an infinitesimal amount of time.”
Jorge Cham, PhD comics 8/20/2010 10. Vertraagde aflevering speelt zowel een rol bij het transport van vaccins als bij dat van mensen.
11. Voor buitenstaanders moet het toch een opluchting zijn als je na 4 jaar promoveren eindelijk
“afstudeert”.
12. Een bezoek aan een ontwikkelingsland doet je beseffen dat we in Nederland in plaats van te klagen, blij moeten zijn dat we het zo verschrikkelijk goed hebben.
