University of Groningen
Sensing Penicillin Volz, Esther
DOI:
10.33612/diss.124807545
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Volz, E. (2020). Sensing Penicillin: Design and construction of Metabolite Biosensors. University of Groningen. https://doi.org/10.33612/diss.124807545
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Propositions
Associated with the PhD Thesis
Sensing Penicillin
Design and construction of metabolite biosensors Esther Magano Volz
1) The successful development of biosensors is strongly dependent on the complexity of the microorganism and the molecular structure of the target molecule.
2) DNA aptamers appear to be unsuitable for the detection of extracellular fungal secondary metabolites (Chapter 2).
3) The role of TcaR in bacterial metabolism is not yet fully understood (Chapter 3). 4) Cell-free systems offer new opportunities to characterize transcription factor-DNA
interactions (Chapter 4).
5) Transcriptional activators could circumenvent many issues that transcriptional repressors cause in vivo when applied as metabolite biosensor (Chapter 5). 6) The future of biosensor development will rather be determined by intensive
screening than by targeted design.
7) In times of abundance of data, one should not forget the importance of drawing meaningful conclusions out of small data sets.
8) People tend to relate to DNA as the basic phenomenon of life, but I tend to
disagree. The concerted conversion of molecules to other molecules is life;
therefore, metabolism is the core of life (Arren Bar-Even).
9) The best way out is always through (Robert Frost).
10) The only way of discovering the limits of the possible is to venture a little way past them into the impossible (Arthur C. Clarke).
11) After all, science is essentially international, and it is only through lack of the historical sense that national qualities have been attributed to it (Marie Curie). 12) Microorganisms are crucial for a bio-based future.
