University of Groningen
G23 peptide-mediated delivery of biodegradable nanocarriers across an in vitro blood-brain barrier model
de Jong, Edwin
DOI:
10.33612/diss.132284892
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
de Jong, E. (2020). G23 peptide-mediated delivery of biodegradable nanocarriers across an in vitro blood-brain barrier model. University of Groningen. https://doi.org/10.33612/diss.132284892
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Stellingen
behorende bij het proefschrift
G23 peptide-mediated delivery of biodegradable
nanocarriers across an in vitro blood-brain barrier model
Ideally, drugs are applied in vivo at exactly the therapeutic concentration and precisely target the cells that cause disease. However, drug delivery is not easily controlled.
Tibbitt et al. (2016) J. Am. Chem. Soc. 138 (3): 704−717.
Sample preparation is the most critical step in fluorescence microscopy experiments, as is clear from the microscopists’ motto ‘garbage in = garbage out’.
Jonkman et al. (2020) Nat. Protoc. 15 (5): 1585−1611.
The usefulness of a blood-brain barrier model is not absolute, but depends on its representational capacity of the selected aspect that is under study.
Naik and Cucullo (2012) J. Pharm. Sci. 101 (4): 1337−1354.
After its endocytosis a molecule is still topologically “outside” the cell, as it is contained in a vesicle, i.e. it is separated from the cell interior by a membrane.
Deprey et al. (2019) Bioconjug. Chem. 30 (4): 1006−1027.
Without an effort in the development of drug delivery systems capable of traversing the blood-brain barrier that is equal to the effort in drug discovery for brain diseases, the current disappointing FDA approval rate of medications to treat brain diseases is not expected to change.
Pardridge (2020) Front. Aging Neurosci. 11: 373.
If you want to go fast, go alone. If you want to go far, go together.
