University of Groningen
The long road
Hilgendorf, Susan
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hilgendorf, S. (2018). The long road: The autophagic network and TP53/ASXL1 aberrations in hematopoietic malignancies. Rijksuniversiteit Groningen.
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STELLINGEN
1. In mouse models, ASXL1 loss needs an additional genetic aberration to promote myeloid malignancies – Abdel-Wahab (Cancer Cell 2012); Abdel-Wahab (JEM 2013)
2. Expression of ASXL1 mutations rather than knockdown of ASXL1 may lead to transformation in xenografts – Inoue (J Clin Invest 2013), Inoue (JEM 2018), this thesis
3. AMLs with TP53 mutations reveal a higher autophagic flux than other AMLs – this thesis
4. Cancer cells can make use of autophagy to become treatment resistant – this thesis
5. TP53 mutations may use their gain-of-function activity to target chromatin regulators and to drive growth of cancer – Zhu (Nature 2015)
6. Treatment of patients can influence clonal evolution – Wong (Blood 2016); Silva-Coelho (Nat Commun 2017); Berger (Blood 2018)
7. “Nur die Harten kommen in den Garten” (only the strongest survive) – my mother
8. “You don’t want to publish porridge” – Peter Doherty 9. Negative results are results – this thesis
10. “I don’t know where I am going, but I am on my way” – Carl Sagan
