University of Groningen Oxygen-releasing biomaterials Steg, Hilde

University of Groningen

Oxygen-releasing biomaterials

Steg, Hilde

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2018

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Steg, H. (2018). Oxygen-releasing biomaterials. Rijksuniversiteit Groningen.

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Oxygen-releasing biomaterials

Oxygen releasing biomaterials

ISBN

978 94 034 1033 3 (printed version)

ISBN

978 94 034 1032 6 (electronic version)

Author

Hilde Steg

Cover/Lay-out Jean Paul Klein

Printed by

Ipskamp Printing b.v.

©2018, H. Steg, Roden, The Netherlands

All rights reserved. No part of this publication may be reproduced or transmitted in any

form by any means, electronical, or mechanical, including photocopy, recording or any

information storage or retrieval system, without the prior written permission of the

copyright owner.

Oxygen-releasing

biomaterials

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

dinsdag 6 november 2018 om 11.00 uur

door

Hilde Steg

geboren op 21 november 1984

te Lelystad

Promotores

Prof. dr. D.W. Grijpma

Prof. dr. S.K. Bulstra

Copromotor

Dr. R. Kuijer

Beoordelingscommissie

Prof. dr. R.R.M. Bos

Prof. dr. R.A. Bank

Prof. dr. D. Stamatialis

Contents

1

2

3

7

5

6

4

Introduction

Review on increasing the viability of seeded cells in implanted tissue

engineering scaffolds

Control of oxygen release from peroxides using polymers

Oxygen-releasing poly(trimethylene carbonate) microspheres for tissue

engineering

Biocompatibility and proof of concept of novel oxygen delivering

microspheres

Culturing of hMSC and SaOs-2 cells on oxygen releasing poly(trimethylene

carbonate) and CaO

composites under hypoxic conditions

General discussion

Summary / Samenvatting

Dankwoord

Curriculum vitae