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University of Groningen Relapse prevention strategies for recurrent depression Klein, Nicola Stephanie

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University of Groningen

Relapse prevention strategies for recurrent depression

Klein, Nicola Stephanie

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Klein, N. S. (2019). Relapse prevention strategies for recurrent depression. Rijksuniversiteit Groningen.

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Relapse prevention strategies

for recurrent depression

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The studies in this dissertation were funded by ZonMW: the Netherlands organization for health research and development (ZonMW Doelmatigheid, kosten en effecten, grant number 171002401; ZonMW Disease Management and Chronic Illnesses, grant number 300020014). The funder had no role in the study design, nor in the collection, analysis, and interpretation of the data.

ISBN

978-94-034-1420-1 (Printed book) 978-94-034-1419-5 (PDF without DRM)

Lay-out design

www.proefschriftopmaak.nl, Groningen

Artwork on the cover and inside the dissertation

Marc Allante, www.marcallante.com and www.society6.com/marcallante

Printed by

Netzodruk Groningen

© 2019, Nicola Stephanie Klein, Groningen, the Netherlands. All rights reserved.

No part of this thesis may be reproduced or transmitted in any form or by any means without the prior permission of the copyright owner.

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ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op donderdag 21 maart 2019 om 16.15 uur

door

Nicola Stephanie Klein

geboren op 14 september 1983 te Botucatu, Brazilië

Relapse prevention strategies

for recurrent depression

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Promotor Prof. dr. C.L.H. Bockting Copromotor Dr. H. Burger Beoordelingscommissie Prof. dr. J. Spijker Prof. dr. T.K. Bouman Prof. dr. M.H. Nauta

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Contents

Chapter 1

General introduction

Chapter 2

Development and validation of a clinical prediction tool to estimate the individual risk of depressive relapse or recurrence in individuals with recurrent depression

Chapter 3

Beliefs about the causes of depression and recovery and their impact on adherence, dosage, and successful tapering of antidepressants

Chapter 4

Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicenter, randomized controlled trial

Chapter 5

Cost-effectiveness, cost-utility, and budget impact of antidepressants versus preventive cognitive therapy with or without tapering antidepressants

Chapter 6

No sustainable effects of an Internet-based relapse prevention program over 24 months in recurrent depression: primary outcomes of a randomized controlled trial

Chapter 7

Economic evaluation of an Internet-based preventive cognitive therapy with minimal therapist support for recurrent depression: results of a randomized controlled trial Chapter 8 General discussion References Nederlandse samenvatting Dankwoord Publication list 9 21 37 53 77 97 111 129 145 163 171 177

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