University of Groningen
Next generation sequencing guided molecular diagnostic tests in non-small-cell lung cancer Wei, Jiacong
DOI:
10.33612/diss.101317239
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wei, J. (2019). Next generation sequencing guided molecular diagnostic tests in non-small-cell lung cancer. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.101317239
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Next Generation Sequencing Guided Molecular
Diagnostic Tests in Non-small-cell Lung Cancer
Wei, J (medgen)
Next generation sequencing guided molecular diagnostic tests in non‐small‐cell lung cancer Thesis, University of Groningen, Groningen, The Netherlands
Printing of this thesis was financially supported by the university of Groningen, the Graduate School of Medical Sciences, University of Groningen.
Cover: Jiacong Wei
Layout: Jiacong Wei
Printed by: Ridderprint, www.ridderprint.nl
ISBN electronic version: ISBN 978‐94‐6375‐591‐7
ISBN printed version: ISBN 978‐94‐6375‐588‐7
Copyright © 2019, J. Wei, The Netherlands
INTRODUCTION
3 Wei, J (medgen)
Next generation sequencing guided molecular diagnostic tests in non‐small‐cell lung cancer Thesis, University of Groningen, Groningen, The Netherlands
Printing of this thesis was financially supported by the university of Groningen, the Graduate School of Medical Sciences, University of Groningen.
Cover: Jiacong Wei
Layout: Jiacong Wei
Printed by: Ridderprint, www.ridderprint.nl
ISBN electronic version: ISBN 978‐94‐6375‐591‐7
ISBN printed version: ISBN 978‐94‐6375‐588‐7
Copyright © 2019, J. Wei, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise without prior written permission of the author.
Next Generation Sequencing Guided Molecular
Diagnostic Tests in Non-small-cell Lung Cancer
PhD thesis
to obtain the degree of PhD at the University of Groningen at the authority
of Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended on public on Tuesday 19 November 2019 at 11.00 hours
by
Jiacong Wei
born on 18 December 1988 in Shandong, China
INTRODUCTION Supervisors
Prof. J.H.M van den Berg Prof. H.J.M. Groen
Co-supervisor
Dr. K. Kok
Assessment Committee
Prof. W.N.M. Dinjens Prof. M. van den Heuvel
Prof. F.A.E Kruyt
Supervisors
Prof. J.H.M van den Berg Prof. H.J.M. Groen
Co-supervisor
Dr. K. Kok
Assessment Committee
Prof. W.N.M. Dinjens Prof. M. van den Heuvel
INTRODUCTION
5
Supervisors
Prof. J.H.M van den Berg Prof. H.J.M. Groen
Co-supervisor
Dr. K. Kok
Assessment Committee
Prof. W.N.M. Dinjens Prof. M. van den Heuvel
Prof. F.A.E Kruyt
Supervisors
Prof. J.H.M van den Berg Prof. H.J.M. Groen
Co-supervisor
Dr. K. Kok
Assessment Committee
Prof. W.N.M. Dinjens Prof. M. van den Heuvel
Prof. F.A.E Kruyt
Paranymphs
Pei Meng
INTRODUCTION
7
Contents
Chapter 1 Introduction 9
Chapter 2 An all‐in‐one transcriptome‐based assay to identify
therapy‐guiding genomic aberrations in non‐small cell lung cancer patients
(in revision to Journal of molecular diagnostics)
19
Chapter 3 Clinical value of EGFR gene amplifications called
based on amplicon‐based targeted next generation sequencing data in lung adenocarcinoma patients
51
Chapter 4 Mutations in EMT‐Related Genes in ALK Positive
Crizotinib Resistant Non‐Small Cell Lung Cancers (Cancers . 2018 Jan 4;10(1). pii: E10)
77
Chapter 5 Targeted sequencing of circulating cell‐free DNA in
stage II‐III resectable oesophageal squamous cell carcinoma patients
(BMC Cancer. 2019 Aug 20;19(1):818)
105
Chapter 6 Summary, discussion and future perspective 137 Nederlandse samenvatting
Acknowledgements
