Tamminga, Menno
DOI:
10.33612/diss.132713141
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tamminga, M. (2020). Circulating tumor cells and the micro-environment in non-small cell lung cancer.
University of Groningen. https://doi.org/10.33612/diss.132713141
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Circulating tumor cells and the micro-environment
in non-small cell lung cancer
Printing:
Ridderprint | www.ridderprint.nl
Copyright © 2020 Menno Tamminga
All rights reserved. No part of this thesis may be reproduced, stored or
trans-mitted in any way or by any means without the prior permission of the author, or
when applicable, of the publishers of the scientific papers.
Circulating tumor cells and the micro-environment
in non-small cell lung cancer
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 30 september 2020 om 11.00 uur
door
Menno Tamminga
geboren op 19 mei 1989
te Hoogeveen
Prof. dr. S. De Jong
Prof. dr. G.A. Huls
Prof. dr. N.H. Stoecklein
Content
Chapter 1 Introduction 7
Chapter 2 Single tube liquid biopsy for advanced non-small cell lung cancer International journal of cancer
31 Chapter 3 Circulating tumor cells in lung cancer are prognostic and predictive
for worse tumor response in both targeted- and chemotherapy Translational lung cancer
61
Chapter 4 Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors
Journal for immunotherapy of cancer
81
Chapter 5 Release of circulating tumor cells during surgery for non-small cell lung cancer: are they what they appear to be?
Clinical cancer research
105
Chapter 6 Diagnostic leukapheresis increases circulating tumor cell yield in non-small cell lung cancer patients.
Submitted
135
Chapter 7 Filtration by microsieves of leukapheresis product for the detection of circulating tumor cells in non-small cell lung cancer patients. Translational lung cancer
167
Chapter 8 Detection of circulating tumor cells in the diagnostic leukapheresis product of non-small cell lung cancer patients; CellSearch® and ISET® compared.
Cancers (Basel)
187
Chapter 9 Molecular loci distinguish lung cancer subtypes and regulation of immune genes
Lung cancer
215
Chapter 10 Immune microenvironment composition in non-small cell lung cancer and its association with survival
Clinical & translational immunology
251
Chapter 11 Discussion 287
Appendix English summary 308
Nederlandse samenvatting 314
Acknowledgements 320
Curriculum Vitae 325
