University of Groningen
Magnesium-based supports for stem cell therapy of vascular disease
Echeverry Rendon, Monica
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Publication date: 2018
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Echeverry Rendon, M. (2018). Magnesium-based supports for stem cell therapy of vascular disease. University of Groningen.
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Magnesium-based supports for stem
cell therapy of vascular disease
The research described in this thesis was performed under an agreement between the University Medical Center Groningen, University of Groningen and Universidad de Antioquia. The work was funded by Colciencias, Eurica and Groningen University Institute for drug exploitation (Guide), Graduate school of medical sciences.
For publication of this thesis, financial support from the Graduate Schoolof medical Science of the University of Gron-ingen/ University Medical Center Groningen and Editekk, Inc is gratefully acknowledged
ISBN: (printer version): 978-94-034-1112-5 ISBN: (digital version): 978-94-034-1111-8
Front cover design: Sebastian Arango & Monica Echeverry R Layout design: Monica Echeverry
Printed by:
© Copyright 2018 Monica Echeverry Rendon
All right reserved. No parts of this publication may be reproduced, stored on retrieval system, or transmitted in any form or by any means, without the permission of the author.
Magnesium-based supports for stem
cell therapy of vascular disease
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 24 October 2018 at 12.45 hours
by
Mónica Echeverry Rendón
born on 31 August 1983Supervisors
Prof. M.C. Harmsen
Prof. F. Echeverria
Co-supervisors
Prof. S. Robledo
Prof. G. Krenning
Assessment Committee
Prof. H.J. Busscher
Prof. A.R. Boccaccini
Prof. H.G.D. Leuvenink
Paranimfen:
Daniela Jou-Valencia
Marloes Sol
CONTENTS
CHAPTER 1Introduction: Contents and aim of the thesis 9
CHAPTER 2 Biodegradable Magnesium-Based Supports for Therapy of Vascular Disease a General View 15
PART I Modification and characterization of Mg by plasma electrolytic oxidation CHAPTER 3 Novel coatings for commercial pure magnesium obtained by plasma electrolytic oxidation through the addition of organic additives 43
CHAPTER 4 Improvement of corrosion resistance of commercial pure magnesium after its modification by single and two-step anodization. 62
CHAPTER 5 Sterilization procedures impact pure magnesium modified by plasma electrolytic oxidation 79
PART II Biological validation of Mg modified by plasma electrolytic oxidation CHAPTER 6 Plasma electrolytic oxidized magnesium adversely influences vascular cells types but not mesenchymal cells and monocytes 92
CHAPTER 7 Endothelial function after exposure to plasma electrolytic oxidized magnesium degradation products 111
CHAPTER 8 General discussion and future perspectives 125
APPENDIX Summary (English) 134 Summary (Dutch) 135 Curriculum vitae 136 List of publications 137 Acknowledgments (English) 139 Acknowledgments (Spanish) 143
