Stem cell therapy for inflammatory bowel disease
Duijvestein, M.
Citation
Duijvestein, M. (2012, February 9). Stem cell therapy for inflammatory bowel disease. Retrieved from https://hdl.handle.net/1887/18462
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/18462
Note: To cite this publication please use the final published version (if applicable).
Stem Cell Therapy for Inflammatory Bowel Disease
Marjolijn Duijvestein
The studies described in this thesis were performed at the Department of Gastroenterology and Hepatology of the Leiden University Medical Center, Leiden, the Netherlands.
Layout: Pepijn Duijvestein Cover photograph: Marjolijn Duijvestein Cover design: Nina Sickenga
ISBN/EAN: 978-90-818537-0-5 Copyright © 2012 M. Duijvestein, Amsterdam, the Netherlands. All rights reserved.
No part of this book may be reproduced or transmitted in any form or by any means, without prior written admission of the author.
Printed by: Haveka, Alblasserdam (www.haveka.nl/greening) This publication (cover and interior) is printed on recycled paper, ReviveⓇ with ink form renewable resources and alcohol free fountain solution.
Recycled, EU Flower, FSC, ISCO 14001
Financial support for the publication of this thesis was kindly provided by ABBOTT Immunology, Bayer HealthCare Pharmaceuticals, ChipSoft B.V., Dr. Falk Pharma Benelux B.V.
Dutch Digestive Foundation (Maag Lever Darm Stichting), EuroTec B.V., J.E. Jurriaanse Stichting, Ferring B.V.
Merck Sharp & Dohme B.V, Netherlands Society of Gastroenterology (NVGE), Olympus Nederland B.V.
Section Experimental Gastroenterology (SEG) of the Netherlands Society of Gastroenterology (NVGE), Tramedico B.V.
Printed by: Haveka, Alblasserdam (www.haveka.nl/greening). This publication (cover and interior) is printed on recycled paper ‘ReviveⓇ’ with ink form renewable resources and alcohol free fountain solution. Recycled, EU Flower, FSC, ISCO 14001
Stem Cell Therapy for Inflammatory Bowel Disease
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P. F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 9 februari 2012
klokke 13.45 uur door
Marjolijn Duijvestein
geboren te Tegucigalpa (Honduras) in 1982
Promotiecommissie
Promotor:!! ! ! ! prof. dr. D. W. Hommes
Co-promotores:! ! ! dr. H. Roelofs
! ! ! ! ! ! ! prof. dr. G.R. van den Brink (Academisch Medisch Centrum, Amsterdam)
Overige leden:! ! ! prof. dr. L. Egan (University of Galway, Galway, Ireland)
! ! ! ! ! ! ! prof. dr. W.E. Fibbe
! ! ! ! ! ! ! prof. dr. F. Koning
! ! ! ! ! ! ! prof. dr. C.L. Mummery
! ! ! ! ! ! ! prof. dr. A.J. Rabelink
! ! ! ! ! ! ! dr. P.C.F. Stokkers (Sint Lucas Andreas Ziekenhuis, Amsterdam)
TABLE OF CONTENTS
Chapter 1!! Introduction
! ! ! ! Journal of Crohn's and Colitis 2008 Jun;2(2):99-106 and Inflammatory Bowel Disease Monitor 2010;11(2):57–64.
Chapter 2!! Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn`s disease
! ! ! ! Journal of Crohn’s and Colitis 2011 Dec;5(6):543-9.
Chapter 3!! Autologous bone marrow derived mesenchymal stromal cell treatment for refractory luminal Crohn’s disease: results of a phase I study
! ! ! ! Gut 2010;59:1662-1669.
Chapter 4!! Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
! ! ! ! Cytotherapy 2011 Oct;13(9):1066-73.
Chapter 5!! Pretreatment with interferon-gamma enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
! ! ! ! Stem Cells 2011 Oct;29(10):1549-58.
Chapter 6 ! Summary, discussion, and future perspectives
! ! ! ! Samenvatting, discussie en toekomstperspectieven Chapter 7!! List of publications
! ! ! ! Curriculum Vitae
! ! ! ! Acknowledgements!
! ! ! ! Abbreviations
9
25
37
53
65
85 89 96 99 100 103
