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University of Groningen

Lipofilling and PRP for aesthetic facial rejuvenation

Willemsen, Joep Carlus Natasja

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Willemsen, J. C. N. (2018). Lipofilling and PRP for aesthetic facial rejuvenation: Understanding and

augmenting the lipograft. Rijksuniversiteit Groningen.

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Understanding and augmenting the lipograft

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Formation and publication of this thesis was possible by generous

contribution from Bergman Clinics

Additional financial and technical support was contributed by:

University of Groningen (RUG)

Groningen University Institute for Drug Exploration (GUIDE) Department of Plastic Surgery University Medical Center Groningen (UMCG)

Willemsen, J.C.N.

Lipofilling and PRP for Aesthetic Facial Rejuvenation: Understanding and augmenting the lipograft ISBN: 978-94-034-0611-4 (printed version)

ISBN: 978-94-034-0610-7 (electronic version) Layout: J.C.N. Willemsen and NCP B.V. Printing: Iskamp printing B.V.

© J.C.N. Willemsen 2018

All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, by photocopying, recording, or otherwise, without

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Lipofilling and PRP for Aesthetic

Facial Rejuvenation

Understanding and augmenting the lipograft

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 11 april 2018 om 12.45 uur

door

Joep Carlus Natasja Willemsen

geboren op 11 oktober 1984

te Zevenaar



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Promotores

Prof. dr. B. van der Lei

Prof. dr. M.C. Harmsen

Copromotor

Dr. H.P.J.D. Stevens

Beoordelingscommissie

Prof. dr. D. Ulrich

Prof. dr. R. van der Hulst

Prof. dr. R.A. Bank

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Paranimfen

Drs. E.J.P.M ten Dam

Drs. A.J.H. Engels



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TABLE OF

CONTENTS

Chapter 1

General introduction and outline of this thesis

8

Chapter 2

Lipofilling in MACS lifting enhances rejuvenation

20

Chapter 3

The effects of platelet rich plasma on recovery time and aesthetic outcome

in facial rejuvenation: preliminary retrospective observations

32

Chapter 4

The addition of PRP to facial lipofilling: a double-blind placebo-controlled

randomized trial

44

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Chapter 6

The power of fat and its adipose-derived stromal cells: emerging concepts

for fibrotic scar treatment

82

Chapter 7

General discussion and future perspectives

108

Chapter 8

Summary

118

Chapter 9

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