University of Groningen
Chronic mucus hypersecretion in COPD and asthma
Tasena, Hataitip
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tasena, H. (2019). Chronic mucus hypersecretion in COPD and asthma: Involvement of microRNAs and stromal cell-epithelium crosstalk. University of Groningen.
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Stellingen | Propositions
related to this thesis
Chronic mucus hypersecretion in COPD and asthma:
Involvement of microRNAs and stromal cell-epithelium crosstalk
1. An unbiased association analysis is not a fishing expedition but can be used to reveal novel pathways underlying chronic mucus hypersecretion. (This thesis)
2. Dysregulated miRNA expression is involved in pathophysiology of chronic mucus hypersecretion in COPD and asthma. (This thesis) 3. miR-134-5p, miR-146a-5p and let-7 family as well as their correlated
targets (e.g. KRAS and EDN1) regulate chronic mucus hypersecretion in COPD. (This thesis)
4. Chronic mucus hypersecretion in COPD and asthma share a common molecular mechanism represented by higher miR-31-5p expression and its negatively correlated targets,
ST3GAL2, PITPNM2, and
ARHGEF15
. (This thesis)5. The long-term co-culture model is a useful tool to study the effects of stromal cells on mucus hypersecretion by epithelial cells. (This thesis) 6. Airway epithelial cells and fibroblasts ‘talk’ to each other, and this
crosstalk promotes epithelial cell differentiation and mucus secretion. (This thesis)
7. Medical research without patient participation is like stroopwafels without caramel.
8. One of the biggest benefits of living abroad is that it helps to strengthen our culture-independent values.
9. A bird sitting on a tree is never afraid of the branch breaking, because its trust is not on the branch but on its own wings. (Charlie Wardle)
