University of Groningen
Electrochemical and enzymatic synthesis of oxidative drug metabolites for metabolism studies
Gül, Turan
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Publication date: 2017
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Gül, T. (2017). Electrochemical and enzymatic synthesis of oxidative drug metabolites for metabolism studies: Exploring selectivity and yield. Rijksuniversiteit Groningen.
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Acknowledgements
With this opportunity I would like to express my gratitude to the individuals who never deprived me of their support throughout my PhD. First of all, I would like to thank my promoter Prof. Rainer Bischoff to give me the opportunity to be part of the Analytical Biochemistry group. I am grateful for your inspiring guidance, invaluable constructive criticism and friendly advice throughout my PhD. I would also like to express my special thanks to my supervisor Dr. Hjalmar Permentier for his continuous support and guidance during my practical work in the laboratory. Many thanks Hjalmar for your valuable contributions on my manuscripts, Dutch translation of my thesis and helping me to solve all the technical problems. I definitely learnt a lot from you.
I am deeply grateful to the assessment committee members; Prof. Gerrit Poelarends, Prof. Frank Dekker and Prof. Herbert Oberacher to spend their valuable time to read my thesis. I would also like to thank Prof. Marco Fraaije and Marzena Krzek for their fruitful collaborations which resulted in a very nice publication. I am very happy to work with colleagues in our STW project and especially I thank Jean-Pierre, Nico and Agnieszka for their kind contributions for my research. I also thank Prof. Peter Horwatowich for his fruitful discussions about Design of Experiments. I must say that Peter apart from the work I enjoyed a lot by playing football with you.
The contribution of my colleagues in Analytical Biochemistry group and Mass Spectrometry Facility could not have been underestimated. Throughout my PhD you all made me feel like a family. I would like to start with my project mates Tao (Larry) Zhang and Tao Yuan (The TTT Team-). Guys I think we did really great job. It was all fun to work with you and share our knowledge and experience to each other. Andries, I am really glad to learn very first basics of Mass Spectrometry from you. I wish I could have learnt more from your knowledge and experience in Mass Spectrometry. I would like to thank our MS-technicians Marcel, Annie and Margot for their endless supports to solve the technical problems in the laboratory. Marcel indeed you were my hero and I learnt a lot from you, thanks for all of your helps. Karin I had quite fun to share the working office with you, thanks for your friendship. I am very glad to have the opportunity to work with Alex, Sara and David. Thanks a lot guys, definitely you were not only colleagues for me but also very good friends. I cannot forget our drinking and game nights. Nico I enjoyed a lot with our talks during the lunch breaks and of course learnt a lot from the Quantitaive Bioanalysis course. I also like to thank our secretary Jolanda for continuous helps with various paper works. I would like to thank also my other colleagues Daniel, Peter Bults, Kees, Natalia, Jos, Jan Willem, Wen Xuan, Jiaying, Georgia, Marcel Kwiatkowski, Daan, Jetse, Vikram, Victor,
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Ansgar, Annalisa D’urzo and Anastasia for their friendship. I also like to thank Wasiq Bawary for his helps during his internship under my supervision.
And of course my very special thanks go to my paranymphs Andres and Frank. I am really happy to know you guys. You definitely made my last couple of years great. We shared a lot together, so you were indeed more than a colleague for me. I will never forget our billiard, table tennis, paintball, laser game, and our board games-. I wish to keep in touch with you for the rest of my life.
Now I would like to thank my special friends who were as close as a family member in Groningen for me. Of course I am talking about the real Başganlar; Ercan-Sanne, Volkan-Bookie, Çağatay-Filiz, Devrim, Kanat-Berfu ve Devrim M. Yazan. We collected really great memories together. You are the ones for sure I will be seeing for the rest of my life. Thanks for your supports and friendship.
I would like to express my sincere gratitude to the big GUTSA family. Hande thanks for introducing GUTSA to me. Funda (without you GUTSA would not have been official), Yağız (without you Groningen nights would not have been that special), Faruk (without you GUTSA talks, food and drinking nights would not have been that spectacular), Seçkin-Pınar (eş başganlarım), Gökhan (bilge adam), Murat (müzik hocam), Şeyda, Arman, Halil, Veclal, İsmail, Behzat (Be-Çee), Agah, Ayşegül, and Elvan. We did really great job together for GUTSA. I thank all of you for sharing your enthusiasm, support and friendship with me. I am also glad to share some nice memories with Yiğit, Meniz, Burcu, Erdal abi, Erdoğan, Mehmet abi, Alp, Yasemin, Aykut başgan, Farid, Barış, Kübra, Şeyma, Mustafa and Tuğba. Ayrıca, Murat abi-Saray abla, Osman abi ve Bayram abi sizleri tanımak benim için büyük bir zevkti. Groningen sizlerle daha güzel, yaptıklarınız için çok teşekkür ediyorum.
I am really glad to meet those great friends, Violetta, Marija, Bibi and Ilche, during my Dutch course. Thanks for your friendship. And Ena, I am very happy to meet you and dance salsa sometimes. I am also grateful to my friends that I met during my Salsa classes, in my weekly indoor football group and the members of the international student associations of Groningen to make Groningen more enjoyable for me.
And another nice person that I met in Groningen: Mea Markvoort. I feel really lucky to stay in your place for four years. You were always friendly and nice to me, thanks for your helps.
Of course I cannot forget my new colleagues in Proxy Laboratories. Within such a short time period you made me to feel as a part of Proxy family. My special thanks go to R&D team, especially Marieke and Ronald for their helps to finalize my last manuscript.
100 Ve sevgili canım ailem, sizlere sahip olduğum için kendimi dünyanın en şanslı insanı olarak hissediyorum. Sizlerin sonsuz sevgisi ve desteği olmasaydı ben bu kadar şeyi başaramayabilirdim. Başta annem, babam ve kardeşlerime göstermiş oldukları fedakarlıklardan dolayı teşekkür ediyorum. Ayrıca ailemizin sevgili büyüğü yakın zamanda kaybettiğim canım dedem /, babannem, halam, amcalarım ve eşlerine ve kuzenlerime bana gösterdikleri maddi-manevi her türlü destek ve emekler için ne kadar teşekkür etsem azdır. Hayat sizlerle daha güzel ve anlamlı, inşallah hep birlikte sağlıklı daha güzel günlere.
Bütün eğitim hayatım boyunca üzerimde emeği olan tüm hocalarıma teşekkürü bir borç biliyorum. Ayrıca abim Serkan Türkeli’ye de bu süreçte bana vermiş olduğu desteklerden dolayı teşekkür ediyorum.
And the last but not least I would like to express my warm thanks to Heli Savolainen for being with me to share many nice moments during the last four years of my life. Heli we collected many nice memmories together and I learnt a lot from you.
Turan Gül,
