University of Groningen
Electrochemical and enzymatic synthesis of oxidative drug metabolites for metabolism studies Gül, Turan
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2017
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Gül, T. (2017). Electrochemical and enzymatic synthesis of oxidative drug metabolites for metabolism studies: Exploring selectivity and yield. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Propositions accompanying the dissertation
Electrochemical and Enzymatic Synthesis of Oxidative Drug Metabolites for
Metabolism Studies: Exploring Selectivity and Yield
by Turan Gül
1. Electrochemistry can be readily combined with mass spectrometry (EC-MS) for product monitoring, facilitating optimization of reaction conditions, and is widely used as an analytical technique to study oxidative drug metabolism (Chapter 2).
2. Electrosynthesis is a promising alternative tool to generate drug metabolites, even though for most metabolites it needs to be improved by at least an order of magnitude in absolute yield to reach the amounts required for follow-up studies (Chapter 2).
3. A multistep DOE strategy is an efficient approach to optimizing the many interacting parameters in EC-driven drug metabolite synthesis reactions covering a broad range of parameters (Chapter 3).
4. Strong acidic conditions suppress the N-dealkylation reaction whereas they favor formation of aromatic hydroxylation metabolites of lidocaine (Chapter 4).
5. Flavin-containing monooxygenases (FMOs), both the mammalian and sequence-related microbial forms, can be used for the very specific production of FMO-related metabolites. This makes them interesting biocatalysts for the production of pharmaceutically relevant drug metabolites (Chapter 5).
6. Success is not the key to happiness. Happiness is the key to success. If you love what you are doing, you will be successful. Albert Schweitzer
7. Try not to become a man of success, but rather try to become a man of value. Albert Einstein 8. Anyone who has never made a mistake has never tried anything new. Albert Einstein
9. Our true mentor in life is science. Mustafa Kemal Atatürk 10. Er gaat niets boven Groningen. Dutch saying
