University of Groningen
Pharmacological approaches to optimize TB treatment
Zuur, Marlies
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Publication date: 2018
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Zuur, M. (2018). Pharmacological approaches to optimize TB treatment: An individualized approach. Rijksuniversiteit Groningen.
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Pharmacological
approaches to optimize
TB treatment
An individualized approach
Marlanka A. Zuur
Zuur, M.A.
Pharmacological approaches to optimize TB treatment; an individualized approach
Thesis, University of Groningen, the Netherlands
Publication of this thesis was financially supported by University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences, KNCV Tuberculosis foundation, Royal Dutch Pharmacists Association (KNMP) and Stichting Beatrixoord Noord-Nederland.
Cover Zuur, M.A.
Layout Zuur, M.A. and Zuur, J.J.
Printed by ProefschriftenPrinten.nl ISBN: 978-94-034-0998-6
ISBN: 978-94-034-0997-9 (electronic version)
© Copyright 2018 M.A. Zuur, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, by photocopying, recording or otherwise, without the prior written permission of the author.
Pharmacological approaches to
optimize TB treatment
An individualized approach
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties
De openbare verdediging zal plaatsvinden op maandag 19 november 2018 om 14:30 uur
door
Marlies Anke Zuur
geboren op 15 januari 1993 te Smallingerland
Promotores
Dr. J.W.C. Alffenaar Prof. dr. T.S. van der Werf Prof. dr. D.J. Touw
Beoordelingscommissie
Prof. dr. J.W. Mouton Prof. dr. M.P. Grobusch Prof. dr. H.A.M. Kerstjens
Chapter 2: Therapeutic drug monitoring of TB drugs: review (page 14)
Chapter 3a: Intermediate Susceptibility Dose-Dependent Breakpoints For High Dose Rifampicin, Isoniazid and
Pyrazinamide, Treatment of MDR-TB in Programmes (page 52)
Chapter 3b: Cost-utility Analysis of Treating Tuberculosis Patients with Intermediate Susceptibility dose-dependent with a Higher
Rifampicin and Isoniazid Dose in Europe (page 74)
Chapter 4: TDM and FDC; friend or foe? (page 98)
Chapter 5a: Quality Assessment of Dried Blood Spots from Tuberculosis Patients from Four Countries (page 106)
Chapter 5b: Dried blood spots can help decrease the burden on patients dually infected with multidrug-resistant tuberculosis and HIV (page 118)
Chapter 6a: Evaluation of carbapenems for multi/extensive-drug resistant Mycobacterium tuberculosis treatment (page 126) Chapter 6b: Pharmacokinetic Modeling and Limited Sampling Strategies based on healthy volunteers for Monitoring of Ertapenem in MDR-TB patients (page 156)
Chapter 6c: Pharmacokinetics of 2,000 Milligram Ertapenem in Tuberculosis Patients (page 174)
Chapter 7: General discussion and future perspectives (page 190)
Summary (page 200) Samenvatting (page 208) Dankwoord (page 216)
About the author: (page 222)
