Photic and non-photic modulation of the mammalian circadian clock
Oosterhout, F.F.T.O. van
Citation
Oosterhout, F. F. T. O. van. (2012, January 12). Photic and non-photic modulation of the mammalian circadian clock. Retrieved from https://hdl.handle.net/1887/18333
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Photic and non-photic modulation
of the mammalian circadian clock
The research of this thesis was supported by Netherlands Organization for Scientific Research (NWO)
Financial support of the printing of this thesis was kindly provided by:
Circularus BV (Den Haag, NL) Addwin Advise BV (Den Haag, NL) Avantes BV (NL)
This thesis is printed on FSC-certified paper
Cover design : Floor van Oosterhout
Print: Gildeprint Drukkerijen, Enschede, The Netherlands ISBN: 978-90-818446-0-4
© 2011 F. van Oosterhout
No part of this thesis may be reproduced without prior permission of the author
Photic and non-photic modulation of the mammalian circadian clock
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 12 januari 2012 klokke 11:15 uur
door
Floortje Francisca Theodora Odilia van Oosterhout
geboren in 1978 te Helmond
PROMOTIECOMMISSIE
Promotor: Prof. Dr. J.H. Meijer
Overige leden: Prof. Dr. R.G. Foster, University of Oxford, UK Prof. Dr. A.M.J.M. van den Maagdenberg Dr. J. Burggraaf, Centre for Human Drug Research
Contents
Chapter 1 Introduction 9
Chapter 2 Correlation with behavioral activity and rest 46 implies circadian regulation by SCN neuronal
activity levels.
Chapter 3 Enhanced circadian phase resetting in R192Q 68 CaV2.1 calcium channel migraine mice.
Chapter 4 Ultraviolet light provides a major input to the 92 circadian system in mice
Chapter 5 The opioid fentanyl affects light input, 118 electrical activity and Per gene expression
in the hamster suprachiasmatic nuclei.
Chapter 6 Amplitude of the SCN electrical activity rhythm 144 enhanced by behavourial activity.
Chapter 7 Discussion, conclusions and implications 165
Summary 186
Nederlandse samenvatting 193
List of Publications 203
Dankwoord 205
Curriculum Vitae 209
